2016—2022年我国17家血液中心献血者HBV感染相关标记物检测情况分析  

Analysis of detection of HBV infection-related biomarkers in blood donors from 17 blood centers of China from 2016 to 2022

作　　者：张莉[1] 车忠民[3] 李玉军[4] 徐今晶 韩卫[6] 温涛[7] 冯惟萍[8] 姚蓓 王瑞涛[10] 李莹[11] 郭咚 李莹[13] 王芳[14] 任星历 王林[16] 肖晨 许婷婷[18] 白林 邱艳[2] Zhang Li;Che Zhongmin;Li Yujun;Xu Jinjing;Han Wei;Wen Tao;Feng Weiping;Yao Bei;Wang Ruitao;Li Ying;Guo Dong;Li Ying;Wang Fang;Ren Xingli;Wang Lin;Xiao Chen;Xu Tingting;Bai Lin;Qiu Yan(Department of Safe Transfusion Lab,Beijing Red Cross Blood Center,Beijing 100088,China)

机构地区：[1]北京市红十字血液中心安全输血研究室,100088 [2]北京市红十字血液中心办公室 [3]云南昆明血液中心行政办 [4]宁夏回族自治区血液中心检验科 [5]天津市血液中心办公室 [6]河北省血液中心检验科 [7]河南省红十字血液中心业务科 [8]甘肃省红十字血液中心检验科 [9]陕西省血液中心采血二科 [10]乌鲁木齐市血液中心检验科 [11]江西省血液中心业务科 [12]长沙血液中心成分献血服务部 [13]成都市血液中心血液检测科 [14]重庆市血液中心检验科 [15]内蒙古自治区血液中心检验科 [16]海南省血液中心质量管理科 [17]山东省血液中心检验科 [18]武汉血液中心检验科 [19]太原市血液中心办公室

出　　处：《北京医学》2024年第8期688-694,共7页Beijing Medical Journal

基　　金：北京市卫生系统高层次卫生技术人才计划(2013-3-101)。

摘　　要：目的探讨我国17家省会城市血液中心(简称血液中心)献血者HBV的感染情况,为安全献血者管理提供参考。方法选取17家血液中心,收集2016—2022年献血者HBsAg和乙型肝炎病毒核酸(HBV DNA)检测结果,比较初次献血者和重复献血者HBsAg不合格率及年度变化趋势、初次献血者和重复献血者HBsAg不合格率差异、HBsAg合格献血者HBV DNA单独不合格(HBsAg-/HBV DNA+)情况和献血者总体HBV不合格率,比较不同地区血液中心献血者总体HBV不合格率。结果2016—2022年17家血液中心初次献血者HBsAg不合格率为59.60‱(1.60‱~142.85‱),重复献血者HBsAg不合格率为16.67‱(0.60‱~48.68‱),HBsAg合格献血者中HBV DNA单独不合格率为6.69‱(1.30‱~17.57‱),献血者总体HBV不合格率为47.06‱(3.46‱~103.78‱),上述4项不合格率的比较,差异均有统计学意义(P<0.05)。东部地区献血者HBV总体不合格率(34.04‱)低于中部地区(50.42‱)和西部地区(52.07‱),3个地区献血者间差异均有统计学意义(P<0.05)。结论17个省会城市初次献血者和重复献血者的HBsAg不合格率随时间整体呈下降趋势,重复献血者是相对安全的献血人群,HBV DNA检测可进一步降低HBV经血传播的风险。献血人群HBV感染分布具有地域性,东部地区献血者HBV不合格率明显低于中西部地区,与一般人群HBV流行分布情况一致。Objective To explore the HBV infection of blood donors in 17 provincial capital cities in China,and to provide reference for the management of safe blood donors.Methods A total of 17 blood centers in China were selected,and the blood screening results from 2016 to 2022 of hepatitis B surface antigen(HBsAg)and hepatitis B virus nucleic acid(HBV DNA)detection of blood donors were collected,and the HBsAg unqualified rates and annual trends among first-time blood donors and repeated blood donors,correlation of HBsAg unqualified results between first-time and repeated blood donors,unqualified results of HBV DNA in HBsAg non reactive donors(HBsAg-/HBVDNA+)and HBV unqualified rate among the total blood donors were statistically analyzed;the overall HBV unqualified rate of blood donors from 17 blood centers in different regions was further calculated and analyzed.Results From 2016 to 2022,the HBsAg unqualified rate of first-time blood donors in 17 blood centers was 59.60/10000(1.6/10000-142.85/10000),while that of repeated blood donors was 16.67/10000(0.60/10000-48.68/10000).The unqualified rate of HBV DNA in non reactive HBsAg donors was 6.69/10000(1.30/10000-17.57/10000).The overall HBV unqualified rate among all blood donors was 47.06/10000(3.46/10000-103.78/10000),and the differences among the above four unqualified rates were statistically significant(P<0.05).The overall unqualified rate of HBV among blood donors in the eastern region(34.04/10000)was lower than that in the central region(50.42/10000)and the western region(52.07/10000),and the differences among blood donors in the three regions were statistically significant(P<0.05).Conclusions The HBsAg unqualified rates of first-time blood donors and repeat blood donors in 17 provincial capital cities have shown an overall downward trend with time.Repeated blood donors are relatively safe blood donors.HBV DNA testing can further reduce the risk of HBV transmission through blood.The distribution of HBV infection among blood donors is regional,and the unqualified rat

关 键 词：HBV HBsAg 初次献血者 重复献血者 乙型肝炎病毒核酸检测 不合格率 

分 类 号：R512.62[医药卫生—内科学] R446.5[医药卫生—临床医学]