颈痹通经验方治疗神经根型颈椎病的临床研究  

Clinical Study on the Treatment of CSR by Jingbitong Empirical Formulas

作　　者：马铮然 杨文龙 候佳晨 杨兴伟 姚敬层 王艳 MA Zheng-ran;YANG Wen-long;HOU Jia-chen;YANG Xing-wei;YAO Jing-ceng;WANG Yan(Dali Bai Autonomous Prefecture Chinese Medicine Hospital,Yunnan Dali 671000,China;School of the Third Clinical Medical Collage of Zhejiang Chinese Medical University,Zhejiang Hangzhou 310053,China;School of Pharmacy,Minzu University of China,Beijing,100081,China)

机构地区：[1]云南省大理白族自治州中医医院,云南大理671000 [2]浙江中医药大学第三临床医学院,浙江杭州310053 [3]中央民族大学药学院,北京100081

出　　处：《中国药物评价》2024年第5期410-413,共4页Chinese Journal of Drug Evaluation

基　　金：云南省科技厅基础研究计划—中医联合专项(202101AZ070001-191);云南中医药大学校院联合—重点项目(XYLH202205);云南中医药大学校院联合基金—滇南医学流派专项(XYLH202327);大理州科技计划—重点研发计划(20242903B030002)。

摘　　要：目的:观察颈痹通经验方干预神经根型颈椎病(cervical spondylotic radiculopathy,CSR)患者的临床疗效,评价其安全性及有效性。探索颈痹通经验方是否能够改善CSR患者的疼痛及颈椎功能,降低复发率。方法:将受试者随机分为对照组和试验组,分别予口服葛根汤和颈痹通经验方。对比两组临床疗效、颈椎功能障碍指数等指标。数据结果应用统计学软件SPSS26.0加以处理。结果:与对照组相比,试验组治疗有效率具有显著性差异(P<0.05)。治疗12天后,主要疗效指标:试验组McGill疼痛量表(the McGill Pain Questionnaire,MPQ)的评分较对照组高,试验组的颈椎功能障碍指数(Neck Disability Index,NDI)评分较对照组低。次要疗效指标:试验组田中靖久颈椎病症状量表评分较治疗前均升高,试验组的中医证候量表评分较对照组低。治疗前后两组的血常规、肝肾功能等血生化指标无明显变化。结论:颈痹通经验方能够改善CSR患者的临床症状及颈椎功能,能够降低复发率。Objective:To observe the clinical efficacy of the Jingbitong empirical formulas in intervening cervical spondylotic radiculopathy(CSR)patients,and evaluate its safety and effectiveness.Exploring whether the prescription Experience of Jingbitong can improve the pain and cervical function of CSR patients,and reduce the recurrence rate.Methods:This study used a central randomization network system to randomly divide participants into a control group and an experimental group.Administer Gegen decoction and Jingbitong formula orally respectively.Compare the clinical efficacy and cervical dysfunction index between two groups.The data results were processed using statistical software SPSS 26.0.Results:Compared with the control group,the experimental group had a higher effective rate of treatment(P<0.05).12 days after treatment,the main efficacy indicators,the McGill Pain Questionnaire(MPQ)score of the experimental group was higher than that of the control group,and the Neck Disability Index(NDI)score of the experimental group was lower than that of the control group.Secondary efficacy indicators:The score of Tanaka Jingjiu's cervical spondylosis symptom scale in the experimental group was higher than that in the control group,and the score of the traditional Chinese medicine syndrome scale in the experimental group was lower than that in the control group.There were no significant changes in blood routine,liver and kidney function,and other blood biochemical indicators between the two groups before and after treatment.Conclusion:The Jingbitong empirical formulas can improve the clinical symptoms and cervical function of CSR patients,and reduce the recurrence rate.

关 键 词：颈痹通经验方 神经根型颈椎病 

分 类 号：R969.4[医药卫生—药理学]