基于“肺合大肠”理论探讨肺纤维化中医病机  

Exploration on the TCM Pathogenesis of Pulmonary Fibrosis Based on the Theory of“Lung Connecting to Large Intestine”

作　　者：董亚伟 朱中博 杨帆 马泉[1,2,4] 李红梅 张艳美[1,2] 何兰兰 张旭辉[1,2,4] 刘喜平 DONG Yawei;ZHU Zhongbo;YANG Fan;MA Quan;LI Hongmei;ZHANG Yanmei;HE Lanlan;ZHANG Xuhui;LIU Xiping(Gansu Provincial Key Laboratory of TCM Prescription Excavation and Innovation Transformation,Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Traditional Chinese Medicine New Product Creation Engineering Laboratory,Gansu University of Chinese Medicine,Lanzhou 730000,China;College of Traditional Chinese Medicine,Hainan Medical University,Haikou 571199,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学甘肃省中医方药挖掘与创新转化重点实验室,甘肃兰州730000 [2]甘肃中医药大学甘肃省中药新产品创制工程实验室,甘肃兰州730000 [3]海南医学院中医学院,海南海口571199 [4]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中国中医药信息杂志》2024年第11期19-23,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金地区科学基金(82260889);甘肃省科技重大项目(22ZD1FA001);甘肃省科技计划项目(20JR5RA165);甘肃省兰州市城关区科技计划项目(2021SHFZ0026)。

摘　　要：肺纤维化是一种以肺泡上皮细胞损伤、成纤维细胞病理性增殖转型、细胞外基质过度沉积导致肺组织结构破坏及功能丧失的呼吸系统疾病,病死率高且尚无较好治疗方法。本文以“肺合大肠”的中医认识即“肺与大肠相表里”理论为基础,以“肺合大肠”的现代医学认识即“肠-肺轴”理论为关键点,结合二者探讨相关机制,初步阐述中医药调控“肠-肺轴”治疗肺纤维化的内涵,为临床通过“肠-肺轴”治疗肺纤维化提供新思路。Pulmonary fibrosis is a respiratory system disorder characterized by damage to alveolar epithelial cells,pathological proliferation and transformation of fibroblasts,excessive deposition of extracellular matrix,leading to structural damage and loss of function in lung tissues,with a high mortality rate and limited effective treatment methods.This article was based on the TCM understanding of“lung connecting to large intestine”,namely the theory of“lung and the large intestine being interior-exterior related”,and set the modern medical understanding of“lung connecting to large intestine”,namely the theory of“gut-lung axis”as the key.Combining the TCM pathogenesis of pulmonary fibrosis and the related mechanisms of“gut-lung axis”in pulmonary fibrosis,it preliminarily expounded the connotation of TCM regulating the“gut-lung axis”to treat pulmonary fibrosis,aiming to provide new ideas for clinical treatment of pulmonary fibrosis through the“gut-lung axis”.

关 键 词：肺合大肠 肺与大肠相表里 肠-肺轴 肺纤维化 肠道微生物 中医药疗法 

分 类 号：R259.63[医药卫生—中西医结合]