网络药理学在中医药领域的研究进展  

Research Progress of Network Pharmacology in the TCM Field

作　　者：张琪 常久 季巍巍[1] 郑宏 向宇雁 刘丽红[1] 朱晓博[2] ZHANG Qi;CHANG Jiu;JI Weiwei;ZHENG Hong;XIANG Yuyan;LIU Lihong;ZHU Xiaobo(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]中国中医科学院,北京100700

出　　处：《中国中医药信息杂志》2024年第11期186-190,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：中国中医科学院科技创新工程(CI2021A05409);中国中医科学院基本科研业务费自主选题(ZZ150316、ZZ150317)。

摘　　要：中药及其复方具有多成分、多靶点和多途径的作用特点,在防治复杂疾病方面具有独特优势。网络药理学可从复杂生物网络角度阐释病证和药物作用机制,挖掘中药的药效物质基础及作用靶点。本文从中医证候生物学基础、中药药效物质基础及作用机制、中药复方配伍理论方面梳理近年中医药领域的网络药理学应用情况,以期为网络药理学在中医药领域的研究应用提供参考。Chinese materia medica and its compound formulas have the characteristics of multi-component,multi-target,and multi pathway effects,and have unique advantages in preventing and treating complex diseases.Network pharmacology explains disease patterns and drug mechanisms from the perspective of complex biological networks,and explores the pharmacological substance basis and target of Chinese medicine.This article summarized the application of network pharmacology from the aspects of biological basis of TCM syndrome,the substance basis and pharmacological mechanism of TCM,compatibility theory of TCM compound formulas,etc.,with the purpose to provide a reference for the research and application of network pharmacology in TCM.

关 键 词：网络药理学 证候 药效物质基础 机制研究 中药配伍 综述 

分 类 号：R285[医药卫生—中药学]