芪参益肾汤治疗脾肾气虚型肾病综合征的疗效及对肾纤维化、炎症反应的影响  

Efficacy of Qishen Yishen Decoction in Treating Spleen-Kidney Qi Deficiency-Type Nephrotic Syndrome and Its Effects on Renal Fibrosis and Inflammatory Response

作　　者：殷娜 曾菁蓉[1] 赵立昌[1] 袁超[1] 相春波 YIN Na;ZENG Jingrong;ZHAO Lichang;YUAN Chao;XIANG Chunbo(Department of Nephrology,Jiangyin Hospital of Traditional Chinese Medicine,Wuxi 214400,China)

机构地区：[1]江阴市中医院肾内科,江苏无锡214400

出　　处：《中医药学报》2024年第11期88-92,共5页Acta Chinese Medicine and Pharmacology

基　　金：江苏省中医药管理局科技项目(YB2023051)。

摘　　要：目的:探究芪参益肾汤治疗脾肾气虚型肾病综合征的疗效及对肾纤维化、炎症反应的影响。方法:选取2020年6月—2023年6月江阴市中医院收治的82例脾肾气虚型肾病综合征患者,按照随机数字表法分为对照组和观察组,各41例,两组均连续治疗8周。统计两组中医证候积分、治疗后的临床疗效、血清透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(C-Ⅳ)、Ⅲ型前胶原(PC-Ⅲ)水平及炎症反应C反应蛋白(CRP)、白介素-6(IL-6)水平,肾功能指标、不良反应。结果:治疗后,观察组中医证候积分显著低于治疗前和对照组(P<0.05)。与对照组相比,观察组总有效率增加(P<0.05)。治疗后,观察组患者的HA、LN、C-Ⅳ、PC-Ⅲ、CRP、IL-6、尿蛋白、血肌酐水平显著低于治疗前和对照组(P<0.05)。观察组的不良反应总发生率为14.63%(6/41),对照组不良反应总发生率为12.20%(5/41),经比较两组差异无统计学意义(P>0.05)。结论:采用芪参益肾汤治疗脾肾气虚型肾病综合征的疗效确切,可以降低患者中医证候积分、炎症反应即肾纤维化发生风险,可改善患者肾功能,且安全性较好。Objective:To investigate the efficacy of Qishen Yishen Decoction in treating spleen-kidney qi deficiency-type nephrotic syndrome and its effects on renal fibrosis and inflammatory response.Methods:A total of 82 patients with spleen-kidney qi deficiency-type nephrotic syndrome,treated at Jiangyin Hospital of Traditional Chinese Medicine from June 2020 to June 2023,were selected.They were randomly divided into a control group and an observation group,with 41 patients in each group.Both groups were treated continuously for 8 weeks.The traditional Chinese medicine syndrome scores,clinical efficacy,serum hyaluronic acid(HA),laminin(LN),type IV collagen(C-IV),type III procollagen(PC-III)levels,inflammatory markers C-reactive protein(CRP)and interleukin-6(IL-6)levels,renal function indicators,and adverse reactions were statistically analyzed.Results:After treatment,the traditional Chinese medicine syndrome scores in the observation group were significantly lower than those before treatment and compared to the control group(P<0.05).The total effective rate was higher in the observation group compared to the control group(P<0.05).Post-treatment,levels of HA,LN,C-IV,PC-III,CRP,IL-6,urine protein,and serum creatinine in the observation group were significantly lower than before treatment and compared to the control group(P<0.05).The overall incidence of adverse reactions in the observation group was 14.63%,while in the control group it was 12.20%,with no statistically significant difference between the two groups(P>0.05).Conclusion:Qishen Yishen Decoction is effective in treating spleen-kidney qi deficiency-type nephrotic syndrome.It can reduce traditional Chinese medicine syndrome scores,inflammatory responses,and the risk of renal fibrosis,and improve renal function with good safety.

关 键 词：芪参益肾汤 中医证候积分 肾病综合征 肾纤维化 炎症反应 

分 类 号：R256.51[医药卫生—中医内科学] R692[医药卫生—中医学]