有创-无创序贯通气疗法联合美罗培南、西维来司他钠治疗急性呼吸窘迫综合征的效果及对炎性因子水平的影响  

Effect of invasive-noninvasive sequential ventilation therapy combined with meropenem and sivelestat sodium in the treatment of acute respiratory distress syndrome and its influences on the levels of inflammatory factors

作　　者：许蕊 宋丹 XU Rui;SONG Dan(Intensive Care Unit 2,Xi'an International Medical Center Hospital,Xi'an 710100,China;Respiratory and Critical Care Medicine Department,Xi'an International Medical Center Hospital,Xi'an 710100,China)

机构地区：[1]西安国际医学中心医院重症医学科,陕西西安710100 [2]西安国际医学中心医院呼吸与危重症医学科,陕西西安710100

出　　处：《临床医学研究与实践》2024年第31期50-53,共4页Clinical Research and Practice

摘　　要：目的探究有创-无创序贯通气疗法联合美罗培南、西维来司他钠治疗急性呼吸窘迫综合征的效果。方法选择2019年2月至2023年1月我院收治的120例急性呼吸窘迫综合征患者为研究对象,以入院时间将其分为对照组和观察组,各60例。对照组接受有创机械通气联合美罗培南、西维来司他钠治疗,观察组接受有创-无创序贯通气疗法联合美罗培南、西维来司他钠治疗。比较两组的治疗效果。结果治疗后,观察组的C-反应蛋白(CRP)、白细胞介素-18(IL-18)、白细胞计数(WBC)及核因子-κB(NF-κB)水平低于对照组(P<0.05)。治疗后,观察组的呼吸系统阻力(Rrs)低于对照组,肺动态顺应性(Crs)、第1秒用力呼吸容积/用力肺活量(FEV1/FVC)高于对照组(P<0.05)。治疗后,观察组的动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))高于对照组,动脉血二氧化碳分压(PaCO_(2))低于对照组(P<0.05)。结论有创-无创序贯通气疗法联合美罗培南、西维来司他钠治疗急性呼吸窘迫综合征患者的效果显著,可调节炎性因子水平,改善肺功能及血氧状态指标。Objective To explore the effect of invasive-noninvasive sequential ventilation therapy combined with meropenem and sivelestat sodium in the treatment of acute respiratory distress syndrome.Methods A total of 120 patients with acute respiratory distress syndrome admitted in our hospital from February 2019 to January 2023 were selected as the research objects.The patients were divided into control group and observation group according to the time of admission,with 60 cases in each group.The control group received invasive mechanical ventilation combined with meropenem and sivelestat sodium,and the observation group received invasive-noninvasive sequential ventilation therapy combined with meropenem and sivelestat sodium.The therapeutic effects of the two groups were compared.Results After treatment,the levels of C-reactive protein(CRP),interleukin-18(IL-18),white blood cell count(WBC)and nuclear factor-κB(NF-κB)in the observation group were lower than those in the control group(P<0.05).After treatment,the respiratory resistance system(Rrs)of the observation group was lower than that of the control group,and the compliance of the respiratory system(Crs)and forced expiratory volume in one second/forced vital capacity(FEV1/FVC)were higher than those in the control group(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO_(2))and arterial oxygen saturation(SaO_(2))in the observation group were higher than those in the control group,and the arterial partial pressure of carbon dioxide(PaCO_(2))was lower than that in the control group(P<0.05).Conclusion Invasive-noninvasive sequential ventilation therapy combined with meropenem and sivelestat sodium has a significant effect in the treatment of patients with acute respiratory distress syndrome,it can regulate the levels of inflammatory factors,improve lung function and blood oxygen status indicators.

关 键 词：有创-无创序贯通气疗法 美罗培南 西维来司他钠 急性呼吸窘迫综合征 炎性因子 

分 类 号：R563.9[医药卫生—呼吸系统]