替罗非班冠状动脉与静脉给药对急性心肌梗死患者PCI术后血管内皮损伤及心脏微循环的影响  

Effects of coronary and intravenous administration of tirofiban on vascular endothelial injury and cardiac microcirculation in patients with acute myocardial infarction after PCI

作　　者：梁燕华[1] 陈述[2] 高娜 LIANG Yanhua;CHEN Shu;GAO Na(Baoji Second People's Hospital,Baoji 721000;Baoji Central Hospital,Baoji 721000,China)

机构地区：[1]宝鸡市第二人民医院,陕西宝鸡721000 [2]宝鸡市中心医院,陕西宝鸡721000

出　　处：《临床医学研究与实践》2024年第31期54-57,共4页Clinical Research and Practice

摘　　要：目的探讨替罗非班冠状动脉与静脉给药对急性心肌梗死患者经皮冠状动脉介入治疗(PCI)术后血管内皮损伤及心脏微循环的影响。方法选择2020年2月至2022年12月收治的126例急性心肌梗死PCI术后患者为研究对象,根据治疗方案的不同将其分为对照组、观察组,每组63例。对照组给予常规对症治疗+替罗非班静脉给药,观察组给予常规对症治疗+替罗非班冠状动脉给药。比较两组的治疗效果。结果治疗后,观察组的内皮素-1(ET-1)水平低于对照组,一氧化氮(NO)、血管内皮生长因子(VEGF)水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的心肌肌钙蛋白I(cTnI)、N-末端B型脑钠肽前体(NT-proBNP)、肌酸激酶同工酶(CK-MB)及肌红蛋白(Mb)水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的左室射血分数(LVEF)、无氧阈值(AT)大于对照组,左心室舒张末期内径(LVEDD)小于对照组,差异具有统计学意义(P<0.05)。结论替罗非班冠状动脉给药可更好地缓解急性心肌梗死患者PCI术后血管内皮损伤,改善心脏微循环,促进心功能恢复,值得推广。Objective To investigate the effects coronary and intravenous administration of tirofiban on vascular endothelial injury and cardiac microcirculation in patients with acute myocardial infarction after percutaneous coronary intervention(PCI).Methods A total of 126 patients with acute myocardial infarction after PCI admitted from February 2020 to December 2022 were selected as the research objects.According to different treatment schemes,and the patients were divided into control group and observation group,with 63 cases in each group.The control group was given routine symptomatic treatment+tirofiban intravenous administration,and the observation group was given routine symptomatic treatment+tirofiban coronary administration.The therapeutic effects of the two groups were compared.Results After treatment,the level of endothelin-1(ET-1)in the observation group was lower than that in the control group,and the levels of nitric oxide(NO)and vascular endothelial growth factor(VEGF)were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of cardiac troponin I(cTnI),N-terminal pro-B-type brain natriuretic peptide(NT-proBNP),creatine kinase isoenzyme(CK-MB)and myoglobin(Mb)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)and anaerobic threshold(AT)in the observation group were larger than those in the control group,and the left ventricular end-diastolic diameter(LVEDD)was smaller than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Tirofiban coronary administration can better alleviate vascular endothelial injury after PCI in patients with acute myocardial infarction,improve cardiac microcirculation,and promote cardiac function recovery,which is worthy of promotion.

关 键 词：替罗非班 急性心肌梗死 经皮冠状动脉介入治疗 血管内皮损伤 心脏微循环 

分 类 号：R969.4[医药卫生—药理学]