小剂量琥珀胆碱预注法对无抽搐电休克治疗精神疾病患者麻醉效果和认知功能的影响  

Effects of low-dose succinylcholine pre-injection method on anesthetic effect and cognitive function in patients with mental illness treated with modified electric convulsive therapy

作　　者：费海涛 FEI Haitao(Wuxi Mental Health Center/Mental Health Center Affiliated to Jiangnan University,Wuxi 214151,China)

机构地区：[1]无锡市精神卫生中心/江南大学附属精神卫生中心,江苏无锡214151

出　　处：《临床医学研究与实践》2024年第31期111-114,共4页Clinical Research and Practice

摘　　要：目的探讨小剂量琥珀胆碱预注法对无抽搐电休克(MECT)治疗精神疾病患者麻醉效果和认知功能的影响。方法选择2022年3月至2023年9月接受MECT治疗的80例精神疾病患者作为研究对象,采用随机数字表法将其分为对照组和研究组,各40例。对照组静脉注射5 mL生理盐水+2.0 mg/kg丙泊酚+1.4 mg/kg琥珀胆碱,研究组静脉注射0.2 mg/kg琥珀胆碱(生理盐水稀释至5 mL)+2.0 mg/kg丙泊酚+1.2 mg/kg琥珀胆碱。比较两组的生命体征指标[给药前(T_(1))、通电后1 min(T_(2))、通电后3 min(T_(3))的平均动脉压(MAP)和心率(HR)]、麻醉苏醒情况(抽搐时间、呼吸恢复时间、苏醒时间、定向力恢复时间)以及认知功能[麻醉前(T_(0))、麻醉苏醒后2 h(T_(4))、麻醉苏醒后4 h(T_(5))的简易精神状态评估量表(MMSE)评分]。结果T_(2),研究组的MAP、HR低于对照组(P<0.05);T_(2)、T_(3),两组的MAP、HR均高于T_(1)(P<0.05)。两组的抽搐时间无明显差异(P>0.05);研究组的呼吸恢复时间、苏醒时间、定向力恢复时间均短于对照组,差异具有统计学意义(P<0.05)。T_(4)、T_(5),研究组的MMSE评分高于对照组(P<0.05)。结论小剂量琥珀胆碱预注法能够有效稳定MECT治疗精神疾病患者的MAP、HR,缩短呼吸恢复时间、苏醒时间及定向力恢复时间,提高患者的认知功能,整体麻醉效果较好。Objective To investigate the effects of low-dose succinylcholine pre-injection method on anesthetic effect and cognitive function in patients with mental illness treated with modified electric convulsive therapy(MECT).Methods A total of 80 patients with mental illness who received MECT treatment from March 2022 to September 2023 were selected as the research objects,the patients were divided into control group and study group by random number table method,with 40 cases in each group.The control group was intravenously injected of 5 mL physiological saline+2.0 mg/kg propofol+1.4 mg/kg succinylcholine,and the study group was intravenously injected of 0.2 mg/kg succinylcholine(diluted to 5 mL with physiological saline)+2.0 mg/kg propofol+1.2 mg/kg succinylcholine.The vital signs indexes[mean arterial pressure(MAP)and heart rate(HR)before administration(T_(1)),1 min after electrification(T_(2))and 3 min after electrification(T_(3))],anesthesia recovery(convulsion time,respiratory recovery time,recovery time and orientation recovery time)and cognitive function[the score of Mini-Mental State Examination(MMSE)before anesthesia(T_(0)),2 h after anesthesia recovery(T_(4))and 4 h after anesthesia recovery(T_(5))]were compared between the two groups.Results At T_(2),the MAP and HR of the study group were lower than those of the control group(P<0.05);at T_(2) and T_(3),the MAP and HR of the two groups were higher than those at T_(1)(P<0.05).There was no significant difference in convulsion time between the two groups(P>0.05);the respiratory recovery time,recovery time and orientation recovery time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).At T_(4) and T_(5),the score of MMSE in the study group was higher than that of the control group(P<0.05).Conclusion The low-dose succinylcholine pre-injection method can effectively stabilize the MAP and HR of patients with mental illness treated by MECT,shorten the respiratory recovery time,recovery time and

关 键 词：琥珀胆碱 预注法 无抽搐电休克治疗 认知功能 

分 类 号：R614.2[医药卫生—麻醉学]