Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors  

作　　者：Brenda Krishnacoumar Martin Stenzel Hilal Garibagaoglu Yasunori Omata Rachel L.Sworn Thea Hofmann Natacha Ipseiz Magdalena A.Czubala Ulrike Steffen Antonio Maccataio Cornelia Stoll Christina Böhm Martin Herrmann Stefan Uderhardt Robert H.Jenkins Philip R.Taylor Anika Grüneboom Mario M.Zaiss Georg Schett Gerhard Krönke Carina Scholtysek 

机构地区：[1]Department of Internal Medicine 3-Rheumatology and Immunology,Friedrich-Alexander University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen,91054 Erlangen,Germany [2]Deutsches Zentrum für Immuntherapie(DZI),Friedrich-Alexander University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen,91054 Erlangen,Germany [3]Department of Biopsectroscopy,Leibniz Institut für Analytische Wissenschaften-ISAS-e.V.,Bunsen-Kirchhoff-Str.11,Dortmund 44227,Germany [4]Medical Faculty,University Hospital,University Duisburg-Essen,Essen 45147,Germany [5]Systems Immunity Research Institute,Heath Park,Cardiff University,Cardiff CF144XN,UK [6]Optical Imaging Competence Centre(FAU OICE),Exploratory Research Unit,Friedrich-Alexander University Erlangen-Nürnberg(FAU),Erlangen,Germany [7]Division of Infection&Immunity,Heath Park,Cardiff University,Cardiff CF144XN,UK [8]Deutsches Rheuma-Forschungszentrum Berlin,Berlin,Germany [9]Department of Rheumatology and Clinical Immunology,Charité-Universitätsmedizin Berlin,Berlin,Germany

出　　处：《Bone Research》2024年第3期611-620,共10页骨研究（英文版）

基　　金：supported by the Bayerische Forschungsstiftung to B.K.;the Deutsche Forschungsgemeinschaft (CRC1181 to G.K.and G.S.;SCHE 2062/1-1 to C.S.);funded by the Wellcome Trust Investigator Award (107964/Z/15/Z);the UK Dementia Research Institute;funded by BBSRC Discovery Fellowship (BB/T009543/1)。

摘　　要：Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.However,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely understood.Here we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion.

关 键 词：INCOMPLETE EXACT ACTIVATION 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]