血清孕酮与β-HCG联合检测对先兆流产的诊断意义  

Diagnostic significance of combined test of serum progesterone andβ-HCG in threatened abortion

作　　者：熊彩虹 陈素贞 XIONG Cai-hong;CHEN Su-zhen(Department of Obstetrics and Gynecology,Yinglin Town Central Health Center,Jinjiang 362261,China)

机构地区：[1]晋江市英林镇中心卫生院妇产科,362261 [2]晋江市第二医院妇产科,362261

出　　处：《中国现代药物应用》2024年第20期73-76,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析在先兆流产早期诊断中采用人绒毛膜促性腺激素(β-HCG)、孕酮联合检测的诊断价值。方法将56例先兆流产孕妇纳入研究组,将60例正常妊娠的孕妇纳入对照组。研究组患者给予孕激素药物、天然维生素E口服进行保胎治疗,两组均进行血清孕酮、β-HCG水平检测。比较两组以及研究组保胎失败患者和继续妊娠患者血清β-HCG、孕酮水平,分析血清β-HCG、孕酮水平与先兆流产的相关性;绘制受试者工作特征(ROC)曲线,分析血清孕酮、β-HCG检测对先兆流产的诊断价值。结果治疗前,相比于对照组的(11768.34±2452.49)IU/L、(32.87±4.54)ng/ml,研究组血清β-HCG(5860.22±1377.62)IU/L、孕酮(14.76±4.75)ng/ml较低(P<0.05)。研究组经治疗后,最终保胎失败孕妇12例,继续妊娠孕妇44例。治疗3 d后,相比于保胎失败孕妇的(6287.56±378.29)IU/L、(22.65±4.86)ng/ml,继续妊娠孕妇的血清β-HCG(9635.63±561.90)IU/L、孕酮(28.86±4.96)ng/ml更高(P<0.05)。血清β-HCG、孕酮水平与先兆流产呈负相关(P<0.05)。血清孕酮、β-HCG单一检测及联合检测的曲线下面积(AUC)分别为0.794、0.812、0.863,血清孕酮与β-HCG联合检测的诊断价值明显更高。结论在先兆流产诊断中,血清孕酮、β-HCG联合检测的诊断效能较高,还可预测其妊娠结局。Objective To analyze the diagnostic value of combined test of serum progesterone andβ-human chorionic gonadotropin(β-HCG)in threatened abortion.Methods 56 cases of threatened abortion patients were included in the study group,and 60 pregnant women with normal pregnancy were included in the control group.Patients in the study group were given progesterone drugs and natural vitamin E orally for fetal preservation treatment,and serum progesterone andβ-HCG levels were detected in both groups.The serumβ-HCG and progesterone levels were compared between the two groups,as well as between the patients with fetal preservation failure and those with continued pregnancy in the study group,the correlation of the serumβ-HCG and progesterone levels with threatened abortion was analyzed;and the receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of the serum progesterone andβ-HCG tests for threatened abortion.Results Before treatment,the study group had serumβ-HCG of(5860.22±1377.62)IU/L and progesterone of(14.76±4.75)ng/ml,which were lower than(11768.34±2452.49)IU/L and(32.87±4.54)ng/ml in the control group(P<0.05).After treatment,there were 12 cases of fetal preservation failure and 44 cases of continued pregnancy in the study group.In patients with continued pregnancy,the serumβ-HCG was(9635.63±561.90)IU/L and the progesterone was(28.86±4.96)ng/ml after 3 d of treatment,which were higher than(6287.56±378.29)IU/L and(22.65±4.86)ng/ml in patients with fetal preservation failure(P<0.05).Serumβ-HCG and progesterone levels were negatively correlated with threatened abortion(P<0.05).The area under the curve(AUC)of serum progesterone,β-HCG single test and combined test were 0.794,0.812 and 0.863,respectively,and the diagnostic value of serum progesterone andβ-HCG combined test was significantly higher.Conclusion The combined test of serum progesterone andβ-HCG has high diagnostic efficiency for threatened abortion and also can predict the pregnancy outcome.

关 键 词：先兆流产 血清孕酮 人绒毛膜促性腺激素 

分 类 号：R714.21[医药卫生—妇产科学]