罗沙司他联合生血宁中西医结合治疗肾性贫血的疗效观察  

Observation on efficacy of combined traditional Chinese and western medicine treatment of renal anemia with roxadustat and Shengxuening in the treatment of renal anemia

作　　者：林金平 黄泽燕 吴良椿 刘筱颖 赖丽琴 刘思婷 LIN Jin-ping;HUANG Zeyan;WU Liang-chun(Quanzhou Quangang District Hospital,Quanzhou 362800,China)

机构地区：[1]泉州市泉港区医院,362800

出　　处：《中国现代药物应用》2024年第20期112-114,共3页Chinese Journal of Modern Drug Application

基　　金：福建省泉州市泉港区科技计划项目(项目编号:2022YL001)。

摘　　要：目的观察罗沙司他联合生血宁中西医结合治疗肾性贫血的效果。方法选取肾性贫血患者90例,按随机数字表法分为A组、B组及C组,每组30例。A组口服罗沙司他及生血宁治疗,B组口服罗沙司他及琥珀酸亚铁缓释片治疗,C组仅口服罗沙司他治疗。比较三组治疗前后血红蛋白(Hb)、红细胞比容(Hct)、血清铁蛋白(SF)水平及中医证候积分、不良反应发生情况。结果治疗后,三组Hb、Hct、SF均高于治疗前,且A组的Hb(112.83±14.77)g/L、Hct(37.10±10.98)%、SF(267.11±54.65)μg/L高于B组的(99.62±17.78)g/L、(30.61±5.44)%、(219.81±63.70)μg/L及C组的(102.76±15.38)g/L、(31.86±4.64)%、(209.82±60.93)μg/L,均具有统计学意义(P<0.05);B组和C组Hb、Hct、SF比较,差异无统计学意义(P>0.05)。治疗后,三组怠倦乏力、面色无华、食欲不振积分均低于治疗前,且A组怠倦乏力积分(1.33±0.60)分、面色无华积分(1.36±0.49)分、食欲不振积分(1.13±0.34)分低于B组的(1.73±0.62)、(1.70±0.74)、(1.50±0.73)分及C组的(1.80±0.76)、(1.76±0.62)、(1.50±0.57)分,均具有统计学意义(P<0.05);B组和C组怠倦乏力、面色无华、食欲不振积分比较,差异无统计学意义(P>0.05)。B组不良反应发生率为6.7%,A组及C组均未出现不良反应。三组不良反应发生率比较,差异无统计学意义(P>0.05)。结论罗沙司他联合生血宁中西医结合治疗肾性贫血较联合琥珀酸亚铁或单用罗沙司他效果显著,且未出现不良反应。Objective To observe the effect of combined traditional Chinese and western medicine treatment of renal anemia with roxadustat and Shengxuening.Methods 90 patients with renal anemia were divided into group A,group B and group C according to random numerical table,with 30 people in each group.Group A was treated with oral roxadustat and Shengxuening,group B was treated with oral roxadustat and ferrous succinate sustained release tablets,and group C was only treated with oral roxadustat.The levels of hemoglobin(Hb),hematocrit(Hct),serum ferritin(SF)and traditional Chinese medicine syndrome score before and after treatment,and the occurrence of adverse reactions were compared among the three groups.Results After treatment,Hb,Hct and SF in the three groups were higher than those before treatment;group A had Hb of(112.83±14.77)g/L,Hct of(37.10±10.98)%and SF of(267.11±54.65)μg/L,which were higher than(99.62±17.78)g/L,(30.61±5.44)%and(219.81±63.70)μg/L in group B,and(102.76±15.38)g/L,(31.86±4.64)%and(209.82±60.93)μg/L in group C;there were statistical significance(P<0.05).There was no significant difference in Hb,Hct and SF between group B and group C(P>0.05).After treatment,the scores of tiredness and fatigue,pale complexion and loss of appetite in the three groups were lower than those before treatment;in group A,the score of tiredness and fatigue was(1.33±0.60)points,the score of pale complexion was(1.36±0.49)points and the score of loss of appetite was(1.13±0.34)points,which were lower than(1.73±0.62),(1.70±0.74)and(1.50±0.73)points in group B,and(1.80±0.76),(1.76±0.62)and(1.50±0.57)points in group C;there were statistical significance(P<0.05).Comparison of the scores of tiredness and fatigue,pale complexion and loss of appetite in group B and group C,the difference was not statistically significant(P>0.05).The incidence rate of adverse reactions in group B was 6.7%,and there were no adverse reactions in group A and group C.Comparison of the incidence of adverse reactions among the three groups

关 键 词：肾性贫血 慢性肾脏病 罗沙司他胶囊 生血宁片 琥珀酸亚铁缓释片 中西医结合 

分 类 号：R692.5[医药卫生—泌尿科学] R556[医药卫生—外科学]