维生素D在儿童肥胖中的应用效果及对瘦素、胰岛素抵抗水平的影响  

Effects of Vitamin D on Obesity in Children and its Effects on Leptin and Insulin Resistance

作　　者：胡慧中 刘宇阳 郭改玲 HU Huizhong;LIU Yuyang;GUO Gailing(Department of Pediatrics,Xi'an No.3 Hospital,Xi'an Shaanxi 710000)

机构地区：[1]西安市第三医院儿科,陕西西安710000

出　　处：《医学临床研究》2024年第10期1540-1542,1546,共4页Journal of Clinical Research

摘　　要：【目的】探讨维生素D在儿童肥胖中的应用效果及对瘦素、胰岛素抵抗水平的影响。【方法】回顾性分析2022年1月至2023年1月本院收治的150例肥胖患儿的临床资料,根据治疗方法不同将其分为观察组(在对照组的基础上给予维生素D治疗)和对照组(采用常规治疗),每组75例。比较两组体重指数(BMI)、25羟基维生素D[25(OH)D]、瘦素、胰岛素抵抗指数(HOMA-IR)、炎症因子[白介素-8(IL-8)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、活性氧(ROS)]。【结果】两组患儿治疗前后身高比较,差异无统计学意义(P>0.05);治疗后,两组患儿BMI低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组25(OH)D均高于治疗前,瘦素、HOMA-IR低于治疗前,且观察组25(OH)D高于对照组,瘦素、HOMA-IR低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清IL-8、IL-6、TNF-α、SOD、MDA、ROS水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。【结论】维生素D能够降低肥胖患儿BMI,减轻患儿机体炎症反应及氧化应激反应,提高瘦素水平,降低HOMA-IR,应用效果良好。【Objective】To investigate the effect of vitamin D in the treatment of childhood obesity and its effect on leptin and insulin resistance.【Methods】The clinical data of 150 obese children admitted to our hospital from January 2022 to January 2023 were retrospectively analyzed,and they were divided into observation group(vitamin D treatment on the basis of control group)and control group(conventional treatment)according to treatment methods,with 75 cases in each group.Body weight indexes,25 hydroxyvitamin D[25(OH)D],leptin,insulin resistance index(HOMA-IR),inflammatory factors[interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],oxidative stress indexes[superoxide dismutase(SOD),malondialdehyde(MDA)and reactive oxygen species(ROS)]of the two groups were compared.【Results】There was no significant difference in height between the two groups before and after treatment(P>0.05).After treatment,the BMI of the two groups was lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After treatment,25(OH)D in both groups was higher than before treatment,leptin and HOMA-IR were lower than before treatment,25(OH)D in the observation group was higher than the control group,leptin and HOMA-IR were lower than the control group,the difference was statistically significant(P<0.05).After treatment,serum levels of IL-8,IL-6,TNF-α,SOD,MDA and ROS in 2 groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).【Conclusion】Vitamin D can reduce the body mass index of obese children,improve the inflammatory response and oxidative stress response of children,increase the level of leptin,reduce HOMA-IR,and the application effect is good.

关 键 词：儿童肥胖 维生素D/治疗应用 瘦素 胰岛素抵抗 

分 类 号：R725.892.5[医药卫生—儿科]