气体标准物质研究中方法检出限的评估  

Evaluation of Detection Limits of Methods in the Study of Gas Reference Materials

作　　者：赵洁 杨扬仲夫 李福芬 李扬 张金波 耿朝阳 那钊宇 张健 孙杰 曲庆 ZHAO Jie;YANG Yangzhongfu;LI Fufen;LI Yang;ZHANG Jinbo;GENG Zhaoyang;NA Zhaoyu;ZHANG Jian;SUN Jie;QU Qing(Ruixinjie Environmental Protection Technology,Beijing 100085,China;National Institute of Metrology,Beijing 100029,China;Dalian Special Gases Co.,Ltd.,Dalian 116620,China;Hangzhou New Century Mixed Gas Co.,Ltd.,Hangzhou 310022,China)

机构地区：[1]北京睿信捷环保科技有限公司,北京100085 [2]中国计量测试学会,北京100029 [3]大连大特气体有限公司,辽宁大连116620 [4]杭州新世纪混合气体有限公司,浙江杭州310022

出　　处：《低温与特气》2024年第5期24-34,共11页Low Temperature and Specialty Gases

摘　　要：为了更好地满足气体标准物质研究中不同方法检出限评估的需求,保证评估结果的可靠性,探讨了气体标准物质研究中常用的信噪比法评估结果的影响因素,并结合国际上检出限评估常用的方法,对气体标准物质研究中常用但不能通过谱图显示基线噪声、不能使用信噪比法的分析方法的检出限评估方法进行了研究,同时,对不同方法评估结果进行了比对和验证,为气体标准物质研究中检出限评估提供多样、可靠的选择。实验结果表明,信噪比法评估时还应考虑载气的纯度、本底样品的干扰、方法线性、样品吸附等的影响;可以使用USEPA方法评估能够通过谱图显示基线噪声的分析方法以及不能通过谱图显示基线噪声的分析方法的检出限,对于能够显示基线噪声的分析方法,USEPA方法评估的检出限水平与信噪比水平相当,比2~3倍信噪比明显偏低;可以使用AOAC方法评估不能显示基线噪声的分析方法的检出限,其值与USEPA方法评估的检出限水平相差不多;信噪比法和AOAC方法评估的检出限均应进行验证,以保证其可靠性,而USEPA方法和目视检查法则无需验证。In order to meet the requirements of different methods for limit of detection evaluation in gas reference materials research and ensure the reliability of evaluation results,this paper discusses the factors affecting the evaluation results of signal-to-noise ratio method commonly used in gas reference materials research,and studies the evaluation methods of limit of detection of analysis methods commonly used in gas reference materials research but unable to display baseline noise through spectrograms and unable to use signal-to-noise ratio method.Meanwhile,the experimental results show that the purity of carrier gas,interference of background sample,linearity of method and adsorption of sample should also be considered in the evaluation of signal-to-noise ratio method.USEPA method can be used to evaluate the detection limit of analytical methods that can show baseline noise and analytical methods that cannot show baseline noise.For analytical methods that can show baseline noise,the detection limit level evaluated by USEPA method is equivalent to the signal-to-noise ratio level,which is significantly lower than 2~3 times the signal-to-noise ratio.AOAC method can be used to evaluate the detection limit of analytical methods that cannot show baseline noise,and its value is similar to the detection limit level evaluated by USEPA method.The detection limits assessed by the signal-to-noise method and AOAC method should be validated to ensure their reliability,while the USEPA method and visual evaluation method do not need validation.

关 键 词：气体标准物质 检出限 评估方法 信噪比法 USEPA AOAC 影响因素 

分 类 号：TQ4[化学工程]