含丝素蛋白多肽结构聚氨酯的制备及其性能  

Synthesis and Properties of Polyurethane Containing Polypeptide from Silk Fibroin

作　　者：洪韵 马晓野[1] 侯靖威 蒋丁晓 康传清[1,2] HONG Yun;MA Xiao-Ye;HOU Jing-Wei;JIANG Ding-Xiao;KANG Chuan-Qing(CAS Key Laboratory of High-Performance Synthetic Rubber and Its Composite Materials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;University of Science and Technology of China,Hefei 230022,China)

机构地区：[1]中国科学院长春应用化学研究所,中国科学院高性能合成橡胶及其复合材料重点实验室,长春130022 [2]中国科学技术大学,合肥230022

出　　处：《应用化学》2024年第10期1425-1435,共11页Chinese Journal of Applied Chemistry

基　　金：吉林省自然科学基金-国家重点实验室重大专项项目(No.SKL202302036)资助。

摘　　要：丝素蛋白因其特殊的多层次结构而具有优异的机械性能。本文研究以丝素蛋白中特征性重复肽段为扩链剂制备的聚氨酯的结构与性能关系,合成了多种含有Gly-Ala-Gly-Ala(GAGA)序列肽段的双氨基扩链剂,并在此基础上制备了一系列多肽含量不同的改性聚氨酯。相较于不含多肽结构的聚氨酯,多肽结构的引入使氢键比例显著提高,由此带来机械性能的显著提升,断裂应力由29.3 MPa提高至50.9 MPa;形状记忆性能也有所提高,形变保持率由74.3%提升至100%,且四肽含量越高,聚氨酯的机械性能和形状记忆性能提升越明显。此外,含多肽扩链剂的聚氨酯还具有良好的回收性、热稳定性和生理条件水解稳定性,具备在生物医学工程等多领域应用的潜力。Silk fibroins have excellent mechanical properties due to their special structure.A variety of diamino chain extenders containing Gly-Ala-Gly-Ala(GAGA)sequence peptides and a series of modified polyurethanes were prepared.The addition of the tetrapeptide-like structure to the backbone improved the ratio of hydrogen bonds of the modified polyurethane,which resulted in a significant increase in mechanical properties with the strain at break increasing from 29.3 to 50.9 MPa.Besides,the shape memory performance of modified polyurethane was also improved with the deformation retention increasing from 74.3%to 100%.Notably,tetrapeptide content positively correlated with the mechanical property and shape memory performance improvements.Additionally,modified polyurethane containing tetrapeptide-like chain extender also had excellent recyclability,thermal stability and hydrolysis stability under physiological conditions,which can be used in various fields and recycled multiple times.

关 键 词：丝素蛋白 聚氨酯 机械性能 形状记忆性能 可回收性 

分 类 号：O633.4[理学—高分子化学]