丙烯酸/壳聚糖季铵盐-柠檬酸强韧湿态黏附水凝胶的制备及性能研究  

Preparation and Properties of a Tough Wet Adhesive Hydrogel of Polyacrylic Acid/Chitosan Quaternary Ammonium Salt-Citric Acid

作　　者：陈润兰 梁子毅 王馨玥 刘海清[1] CHEN Runlan;LIANG Ziyi;WANG Xinyue;LIU Haiqing(College of Chemistry and Materials Science,Fujian Normal University,Fuzhou 350117,China)

机构地区：[1]福建师范大学化学与材料学院,福建福州350117

出　　处：《福建师范大学学报（自然科学版）》2024年第6期1-8,共8页Journal of Fujian Normal University：Natural Science Edition

基　　金：国家自然科学基金资助项目(52103108、22175037);福建省科技厅高校产学研项目(2022H6001)。

摘　　要：组织黏胶是无创伤口闭合的重要医用材料。以丙烯酸、壳聚糖季铵盐(chitosan quaternary ammonium salt,QCS)和柠檬酸(citric acid,CA)为原料,通过一锅法制备了一种强韧湿态组织黏附水凝胶。结果表明,该水凝胶具有双网络结构,聚丙烯酸(polyacrylic acid,PAA)形成第一重网络,QCS穿插其中形成半互穿网络;QCS和CA的交联提供了第二重网络,从而赋予PAA/QCS-CA水凝胶良好的力学性能,其拉伸强度和韧性可达201.0 kPa和819.8 kJ·m^(-3)。此外,该水凝胶对湿态生物组织具有良好的黏附性能,界面韧性最高可达707.7 J·m^(-2)。Wet tissue adhesives are important biomedical materials for non-invasive wound closure.Herein,a tough wet adhesive hydrogel was prepared by a one-pot reaction of acrylic acid,chitosan quaternary ammonium salt(QCS),and citric acid(CA).The hydrogel exhibited a double-network structure,where polyacrylic acid(PAA)formed the primary network,and QCS interpenetrated within it to form a semi-interpenetrating network.The cross-linking between QCS and CA provided the second network,endowing the PAA/QCS-CA hydrogel with high mechanical properties(fracture strength 201.0 kPa,toughness 819.8 kJ·m^(-3))and strong adhesion to wet biological tissues,achieving interfacial toughness up to 707.7 J·m^(-2).

关 键 词：水凝胶 湿态组织 聚丙烯酸 壳聚糖 柠檬酸 黏附 

分 类 号：O63[理学—高分子化学]