金黄色葡萄球菌致膜损伤毒素及拮抗的天然药物研究进展  

Research progress in membrane-damaging toxins of Staphylococcus aureus and natural anti-toxin medicines

作　　者：薛喜博 高毅玖 黄筱琳 毛慧霞 张澳凯 孙英健 XUE Xibo;GAO Yijiu;HUANG Xiaolin;MAO Huixia;ZHANG Aokai;SUN Yingjian(Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Animal Science and Technology College,Beijing University of Agriculture,Beijing 102206,China)

机构地区：[1]北京农学院动物科学技术学院,兽医学(中医药)北京市重点实验室,北京102206

出　　处：《微生物学通报》2024年第10期3822-3835,共14页Microbiology China

基　　金：北京市自然科学基金(6212003);北京农学院科技创新“火花行动”支持计划(BUA-HHXD2022004)。

摘　　要：金黄色葡萄球菌(Staphylococcus aureus)在感染过程中分泌多种毒素,对宿主细胞膜损伤的毒素是其中一类较为关键的毒素。天然药物具有结构多样性、毒性低等特点,因此,从植物、动物、微生物中寻找药物先导化合物具有极好的潜力。本文针对引起细胞膜损伤毒素的性质、结构特点、作用方式进行综述,对部分抗致膜损伤毒素的天然药物进行总结,为今后新型药物的选择和对抗毒素的治疗手段提供依据。Staphylococcus aureus secretes a variety of toxins in the course of infection,and the toxins damaging the host cell membrane have garnered great attention.Natural medicines are characterized by structural diversity and low toxicity,and thus it has great potential to mine lead compounds from plants,animals,and microorganisms.This paper reviews the properties,structural characteristics,and mechanism of membrane-damaging toxins and summarizes the natural medicines against these toxins,providing a basis for the selection of new drugs and the development of anti-toxin therapies in the future.

关 键 词：金黄色葡萄球菌 毒素 天然药物 治疗策略 

分 类 号：S852.61[农业科学—基础兽医学]