血清N末端B型利钠肽原和胰岛素样生长因子结合蛋白7及热休克蛋白47联合检测在慢性心力衰竭患者诊断中的应用价值分析  

Application value of combined detection of serum N-terminal pro-brain natriuretic peptide,insulin-like growth factor binding protein 7 and heat shock protein 47 in the diagnosis of patients with chronic heart failure

作　　者：张华 宋敏 田美蓉 ZHANG Hua;SONG Min;TIAN Mei-rong(Department of Three Cardiovascular Tangshan Central Hospital,Tangshan 063000,China)

机构地区：[1]唐山中心医院心血管内三科,河北省唐山市063000

出　　处：《中国心血管病研究》2024年第10期884-888,共5页Chinese Journal of Cardiovascular Research

基　　金：河北省医学科学研究课题计划项目(20231793)。

摘　　要：目的探讨血清N末端B型利钠肽原(NT-pro BNP)、胰岛素样生长因子结合蛋白7(IGFBP7)、热休克蛋白47(HSP47)联合检测在慢性心力衰竭(CHF)患者诊断中的应用价值分析。方法选取2021年12月至2023年12月唐山中心医院收治的CHF患者(n=106)为CHF组,另选取同期在本院健康体检者(n=106)为对照组。采用酶联免疫吸附测定法(ELISA)测定两组血清NT-pro BNP、IGFBP7、HSP47表达水平,多因素logistic回归分析影响CHF发生的因素,受试者工作特征(ROC)曲线分析其对CHF患者的诊断价值。结果CHF组血清NT-pro BNP、IGFBP7、HSP47水平与对照组相比,明显升高(t=0.960、8.047、11.196,P<0.05)。血清NT-pro BNP、IGFBP7、HSP47三者联合诊断CHF的AUC最高,高于单独检测(Z_(三者联合-NT-pro BNP)=3.847、P=0.001,Z_(三者联合)-IGFBP7=4.672、P<0.001,Z_(三者联合-HSP47)=2.101、P=0.036)。多因素logistic结果显示,血清NT-pro BNP、IGFBP7、HSP47水平是影响CHF的危险因素(P<0.05),左心室射血分数(LVEF)是影响CHF的保护因素(P<0.05)。结论CHF患者血清中NT-pro BNP、IGFBP7、HSP47表达水平升高,三者联合诊断CHF的效能最好。Objective To explore the application value of combined detection of serum N-terminal pro-brain natriuretic peptide(NT-proBNP),insulin-like growth factor binding protein 7(IGFBP7)and heat shock protein 47(HSP47)in the diagnosis of patients with chronic heart failure(CHF).Methods 106 CHF patients who admitted to our hospital from December 2021 to December 2023 were used as the CHF group,and 106 healthy individuals who underwent physical examinations same time were as the control group.The expression levels of N_(T-proBNP,IGFBP7)and HSP47 in the serum were measured using enzyme-linked immunosorbent assay(ELISA).The factors affecting the occurrence of CHF were analyzed using multiple logistic regression analysis.Diagnostic value of serum NT-proBNP,IGF-BP7 and HSP47 in patients with CHF was analyzed by drawing the receiver’s operating characteristics(ROC)curve.Results Compared with the control group,the expression levels of N_(T-proBNP,IGFBP7)and HSP47 in the serum of the CHF group were obviously increased(t=0.960,8.047,11.196,P<0.05).Multivariate logistic regression showed that serum N_(T-proBNP,IGFBP7)and HSP47 were the risk factors affecting the occurrence of CHF(P<0.05),while left ventricular ejection fraction(LVEF)was a protective factor affecting the occurrence of CHF(P<0.05).The combing test of the serum N_(T-proBNP,IGFBP7)and HSP47 had the highest AUC in the diagnosis of CHF,which was higher than that detected alone(Ztriple combination-NT-proBNP=3.847,P=0.001,Ztriple combination-IGFBP7=4.672,P<0.001,Z_(triple combination-HSP47)=2.101,P=0.036).Conclusion The expression levels of N_(T-proBNP,IGFBP7)and HSP47 in the serum of CHF patients are elevated,and the combing text of the three has the best diagnostic efficacy for CHF.

关 键 词：N末端B型利钠肽原 胰岛素样生长因子结合蛋白7 热休克蛋白47 慢性心力衰竭 诊断 

分 类 号：R541.6[医药卫生—心血管疾病]