基于生物信息学筛选肥胖症与A型主动脉夹层的共同生物标志物  

Identification of common biomarkers between obesity and type A aortic dissection based on bioinformatics analysis

作　　者：王结能 张世明[1] 刘瑞生[1] 孙伟[1] WANG Jie-neng;ZHANG Shi-ming;LIU Rui-sheng;SUN Wei(Department of Cardiac Surgery,The First Hospital of Lanzhou University,730000 Lanzhou,China)

机构地区：[1]兰州大学第一医院心外科,甘肃省兰州市730000

出　　处：《中国心血管病研究》2024年第10期912-917,共6页Chinese Journal of Cardiovascular Research

基　　金：甘肃省自然科学基金(基础研究计划)(22JR11RA037);兰州大学第一医院院内青年基金(ldyyyn2019-106)。

摘　　要：目的筛选肥胖症与A型主动脉夹层(TAAD)的共同生物标志物,为肥胖症患者探索可能的TAAD预测因子。方法从基因表达数据库(gene expression omnibus,GEO)中下载TAAD和肥胖症相关表达谱芯片数据,使用GEO2R筛选差异表达基因,依据Venn图获取差异共表达基因,在DAVID网站进行基因功能注释(gene ontology,GO)和功能富集分析(kyoto encyclopedia of genes and genomes,KEGG),结合STRING网站和Cytoscape 3.8.2软件进行蛋白互作分析。结果从2个数据集筛选得到差异共表达基因30个,鉴别出5个枢纽基因ITGAX,CD163,S100A9,SPP1和IL-6。结论TAAD和肥胖症有着共同的致病基因,它们可能成为A型主动脉夹层合并肥胖症患者的生物学预测因子和潜在药物治疗靶点。Objective To screen the possible shared-biomarkers of predictive factors for obesity and type A aortic dissection(TAAD).Methods The TAAD croarray data related to TAAD and obesity were downloaded from gene expression omnibus(GEO)database.The differentially expressed genes were selected by GEO2R,and the differentially co-expressed genes were obtained ording to the intersection of Venn map.Biological function enrichment of gene ontology(GO)and kyoto encyclopedia of genes and genomes(KEGG)were analyzed via the DAVID website,and protein interaction was analyzed via the STRING website using Cytoscape3.8.2 software.Results A total of 30 DEGs were screened,in which,5 hub genes were identified and biological process analysis revealed:ITGAX,CD163,S100A9,SPP1 and IL-6.Conclusion TAAD and obesity shared some common pathogenic genes,which may be the biological predictors and potential drug targets for TAAD patients with obesity.

关 键 词：A型主动脉夹层 肥胖症 生物信息学 信号通路 蛋白质-蛋白质相互作用 

分 类 号：R543.1[医药卫生—心血管疾病]