复方守宫散对非小细胞肺癌患者免疫功能及肺功能的疗效研究  

Study on the therapeutic effect of compound Shougong powder on pulmonary function in patients with non-small cell lung cancer

作　　者：卢会琴 柳星 祝永福[3] 张涛 么金凤 张童飞 陈果 LU Hui-qin;LIU Xing;ZHU Yong-fu(Anhui Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Hefei 230038,Anhui;不详)

机构地区：[1]安徽省中西医结合医院,安徽合肥230038 [2]安徽中医药大学第二附属医院,安徽合肥230061 [3]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《安徽医专学报》2024年第5期18-20,共3页Journal of Anhui Medical College

基　　金：安徽省卫生健康委科研项目(编号:AHWJ2021b037);安徽中医药大学临床科研项目(编号:2021efylc04)。

摘　　要：目的:观察复方守宫散对非小细胞肺癌(NSCLC)患者免疫功能及肺功能的影响。方法:将60例NSCLC患者随机分为观察组和对照组,每组30例。观察组患者予复方守宫散(每次5 g,每天2次)+常规化疗,对照组患者予常规化疗,3周为1个疗程,共治疗3个疗程。评价患者的中医症状、体征改善情况,检测CD3^(+)、CD8^(+)、CD4^(+)、CD4^(+)/CD8^(+)比值,并检测患者肺功能:用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、最大通气量(MVV)。结果:治疗后,观察组患者治疗总有效率优于对照组,差异有统计学意义(P<0.05);两组患者CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)的比值与治疗前相比均显著降低(P<0.05),CD8^(+)与治疗前比较显著升高(P<0.05)。观察组治疗后CD8^(+)指标显著低于对照组(P<0.05),CD3^(+)与CD4^(+)、CD4^(+)/CD8^(+)比值显著高于对照组患者(P<0.05)。与治疗前比较,两组患者肺功能FVC、FEV_(1)、MVV均明显升高(P<0.05),且观察组患者各指标均明显高于对照组(P<0.05)。结论:NSCLC患者普遍存在肺功能差,从而对患者的生存期及生活质量均产生很大影响,复方守宫散在改善NSCLC患者临床症状的同时,对其免疫功能有一定的提高,并可改善患者的肺功能,最终得以改善患者的生存质量、延长生存期。Objective:To observe the effects of compound Shougong powder on immune function and lung function in patients with non-small cell lung cancer(NSCLC).Method:60 NSCLC patients were randomly divided into an observation group and a control group,with 30 cases in each group.The observation group was treated with Compound Shougong Powder(5g each time,twice a day)and conventional chemotherapy,while the control group was treated with conventional chemotherapy for a total of three courses of treatment,consisting of three weeks.Evaluate the improvement of traditional Chinese medicine symptoms and signs in patients,detect CD3^(+),CD8^(+),CD4^(+),CD4^(+)/CD8^(+)ratio,and measure the patient's lung function:forced vital capacity(FVC),forced expiratory volume at 1 second(FEV_(1)),and maximum ventilation volume(MVV).Result:Comparison of clinical efficacy of traditional Chinese medicine between two groups of patients:The total effective rate of the observation group was better than that of the control group,with a significant difference(P<0.05);In terms of immune function after treatment,the observation group and the control group showed a significant decrease in CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)ratios compared to before treatment(P<0.05),while CD8^(+)was significantly increased compared to before treatment(P<0.05).The comparison of CD8^(+)indicators between the two groups after treatment showed that the observation group was significantly lower than the control group(P<0.05),and the ratio of CD3^(+)to CD4^(+)and CD4^(+)/CD8^(+)was significantly higher than that of the control group patients(P<0.05).Compared with before treatment,the lung function of the two groups of patients showed a significant increase in FVC,FEVi,and MVV(P<0.05).After treatment,the two groups were compared,and all indicators in the observation group were significantly higher than those in the control group(P<0.05).Conclusion:NSCLC patients generally have poor lung function,which has a significant impact on their survival and quality of life.Compound Shoug

关 键 词：复方守宫散 非小细胞肺癌 免疫功能 肺功能 疗效研究 

分 类 号：R273[医药卫生—中西医结合]