Kill two birds with one stone:Hapatologist’s approach to metabolic dysfunction-associated steatotic liver disease and heart failure  

作　　者：Yusuke Hirao Clarke Morihara Tomoki Sempokuya 

机构地区：[1]Department of Medicine,John A Burns School of Medicine,University of Hawaii at Manoa,Honolulu,HI 96813,United States [2]Division of Gastroenterology and Hepatology,Department of Medicine,John A Burns School of Medicine,University of Hawaii at Manoa,Honolulu,HI 96813,United States

出　　处：《World Journal of Cardiology》2024年第11期660-664,共5页世界心脏病学杂志（英文）

摘　　要：Heart failure(HF)is a major global public health concern,and one of the less commonly known risk factors for HF development is metabolic dysfunction-associated steatotic liver disease(MASLD),as they share a similar pathophysio-logical background.In this article,we evaluated a recently published review article by Arriola-Montenegro et al.This article briefly summarizes the common pathophysiology of HF and MASLD development and evaluates the available therapeutic options to treat both conditions.Clinical practice guidelines highlight the importance of initiating and titrating guideline-directed medication therapy(GDMT)for patients with HF with reduced ejection fraction.GDMT is comprised of the four pillars currently proposed in most clinical practice guidelines,namely angiotensin-converting enzyme inhibitors(ACEIs),angiotensin receptor blockers(ARBs),angiotensin receptor-neprilysin inhibitors,beta-blockers,mineralocor-ticoid receptor antagonists,and sodium-glucose co-transporter 2 inhibitors(SGLT-2i).Given the similarity of pathophysiology and risk factors,recent studies for GDMT regarding ACEIs,ARBs,mineralocorticoid receptor antagonists,and SGLT-2i have shown beneficial effects on MASLD.Nonetheless,other medications for both conditions and novel therapies require more robust data and well-designed clinical studies to demonstrate their efficacies in both conditions.

关 键 词：Metabolic dysfunction-associated steatotic liver disease Heart failure Heart failure with reduced ejection fraction NON-PHARMACOLOGICAL Pharmacological Surgical intervention 

分 类 号：R541.6[医药卫生—心血管疾病]