The role of the cGAS-STING signaling pathway in viral infections,inflammatory and autoimmune diseases  

作　　者：Ming-ming Wang Yue Zhao Juan Liu Rong-rong Fan Yan-qing Tang Zheng-yang Guo Ting Li 

机构地区：[1]State Key Laboratory of Quality Research in Chinese Medicine,Macao Institute for Applied Research in Medicine and Health,Macao University of Science and Technology,Macao,999078,China [2]Department of Biosciences and Nutrition,Karolinska Institute,Huddinge,14183,Sweden

出　　处：《Acta Pharmacologica Sinica》2024年第10期1997-2010,共14页中国药理学报（英文版）

基　　金：supported by Macao Science and Technology Development Fund,0058/2020/A,0018/2023/AMJ,011/AIJ/2020 and 0003/2021/AKP;Swedish Research Council(Vetenskapsrådet)2019-01884;Swedish Cancer Foundation(Cancerfonden)200680 Pj;CIMED FoUI-975445.

摘　　要：Pattern recognition receptors are an essential part of the immune system,which detect pathogen-associated molecular patterns(PAMPs)and damage-associated molecular patterns(DAMPs)and help shape both innate and adaptive immune responses.When dsDNA is present,cyclic GMP-AMP Synthase(cGAS)produces a second messenger called cyclic GMP-AMP(cGAMP),which then triggers an adaptor protein called STING,and eventually activates the expression of type I interferon(IFN)and pro-inflammatory cytokines in immune cells.The cGAS-STING signaling pathway has been receiving a lot of attention lately as a key immune-surveillance mediator.In this review,we summarize the present circumstances of the cGAS-STING signaling pathway in viral infections and inflammatory diseases,as well as autoimmune diseases.Modulation of the cGAS-STING signaling pathway provides potential strategies for treating viral infections,inflammatory diseases,and autoimmune diseases.

关 键 词：cGAS-STING signaling pathway type I interferon(IFN) double-stranded DNA(dsDNA) viral infections inflammatory diseases autoimmune diseases 

分 类 号：R392[医药卫生—免疫学]