Endothelial dysfunction:mechanisms and contribution to diseases  

作　　者：Amir Ajoolabady Domenico Pratico Jun Ren 

机构地区：[1]Department of Biomedical Engineering,University of Alabama at Birmingham,Birmingham,AL,35294,USA [2]Alzheimer’s Center at Temple,Lewis Katz School of Medicine,Temple University,Philadelphia,PA,19140,USA [3]Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai Institute of Cardiovascular Diseases,Shanghai,200032,China

出　　处：《Acta Pharmacologica Sinica》2024年第10期2023-2031,共9页中国药理学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(82130011,92249301).

摘　　要：The endothelium,lining the inner surface of blood vessels and spanning approximately 3 m^(2),serves as the largest organ in the body.Comprised of endothelial cells,the endothelium interacts with other bodily components including the bloodstream,circulating cells,and the lymphatic system.Functionally,the endothelium primarily synchronizes vascular tone(by balancing vasodilation and vasoconstriction)and prevents vascular inflammation and pathologies.Consequently,endothelial dysfunction disrupts vascular homeostasis,leading to vascular injuries and diseases such as cardiovascular,cerebral,and metabolic diseases.In this opinion/perspective piece,we explore the recently identified mechanisms of endothelial dysfunction across various disease subsets and critically evaluate the strengths and limitations of current therapeutic interventions at the pre-clinical level.

关 键 词：endothelial dysfunction inflammation extracellular matrix and cytoskeleton metabolic conditions HYPERGLYCEMIA 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]