Exploring the impact of hepatitis B immunoglobulin and antiviral interventions to reduce vertical transmission of hepatitis B virus  

作　　者：Dhita Prabasari Wibowo Agustiningsih Agustiningsih Sri Jayanti Caecilia H C Sukowati Korri Elvanita El Khobar 

机构地区：[1]Eijkman Research Center for Molecular Biology,Research Organization for Health,National Research and Innovation Agency of Indonesia,Jakarta 10430,Indonesia [2]Postgraduate School,Faculty of Medicine,Universitas Hasanuddin,Makassar 90245,Indonesia [3]Department of Liver Cancer,Fondazione Italiana Fegato ONLUS,Trieste 34149,Italy

出　　处：《World Journal of Experimental Medicine》2024年第4期6-22,共17页世界实验医学杂志（英文）

基　　金：Supported by Rumah Program 2024 of Research Organization for Health,National Research and Innovation Agency(BRIN)of Indonesia.

摘　　要：Hepatitis B virus(HBV)infection is a major public health burden.In HBV endemic regions,high prevalence is also correlated with the infections acquired in infancy through perinatal transmission or early childhood exposure to HBV,the socalled mother-to-child transmission(MTCT).Children who are infected with HBV at a young age are at higher risk of developing chronic HBV infection than those infected as adults,which may lead to worse clinical outcome.To reduce the incidence of HBV MTCT,several interventions for the infants or the mothers,or both,are already carried out.This review explores the newest information and approaches available in literature regarding HBV MTCT prevalence and its challenges,especially in high HBV endemic countries.This covers HBV screening in pregnant women,prenatal intervention,infant immunoprophylaxis,and postvaccination serological testing for children.

关 键 词：Hepatitis B virus Hepatitis B immunoglobulin Mother-to-child transmission Vertical transmission Antiviral prophylaxis 

分 类 号：R512.62[医药卫生—内科学]