Abnormally activated wingless/integrated signaling modulates tumor-associated macrophage polarization and potentially promotes hepatocarcinoma cell growth  

作　　者：Wei-Lu Wang Paul Kwong Hang Tam Yan Chen 

机构地区：[1]School of Pharmacy,Faculty of Medicine,Macao University of Science and Technology,Macao 999078,China

出　　处：《World Journal of Gastroenterology》2024年第41期4490-4495,共6页世界胃肠病学杂志（英文）

基　　金：Supported by Macao Science and Technology Development Fund,No.0086/2022/A and No.0097/2022/A2.

摘　　要：In this article,we comment on the article by Huang et al.The urgent development of new therapeutic strategies targeting macrophage polarization is critical in the fight against liver cancer.Tumor-associated macrophages(TAMs),primarily of the M2 subtype,are instrumental in cellular communication within the tumor microenvironment and are influenced by various signaling pathways,including the wingless/integrated(Wnt)pathway.Activation of the Wnt signaling pathway is pivotal in promoting M2 TAMs polarization,which in turn can exacerbate hepatocarcinoma cell proliferation and migration.This manuscript emphasizes the burgeoning significance of the Wnt signaling pathway and M2 TAMs polarization in the pathogenesis and progression of liver cancer,highlighting the potential therapeutic benefits of inhibiting the Wnt pathway.Lastly,we point out areas in Huang et al’s study that require further research,providing guidance and new directions for similar studies.

关 键 词：Liver cancer Hepatocarcinoma cell Wingless/integrated signaling pathway M2 tumor-associated macrophages Polarization 

分 类 号：R735.7[医药卫生—肿瘤]