Detection of decline in estimated glomerular filtration rate in patients with type 2 diabetes by cystatin C-based equations  

作　　者：Tam Thai Thanh Tran Tien Kim Ha Nhut Minh Phan Minh Van Le Tin Hoang Nguyen 

机构地区：[1]Department of Physiology,Faculty of Medicine,Can Tho University of Medicine and Pharmacy,Can Tho 900000,Viet Nam [2]Department of Functional Exploration,Can Tho University of Medicine and Pharmacy Hospital,Can Tho 900000,Viet Nam [3]School of Medicine and Pharmacy,The University of Da Nang,Da Nang 550000,Viet Nam [4]Faculty of Medicine,Can Tho University of Medicine and Pharmacy,Can Tho 900000,Viet Nam

出　　处：《World Journal of Nephrology》2024年第4期103-116,共14页世界肾病学杂志（英文）

摘　　要：BACKGROUND Aging population is a significant issue in Viet Nam and across the globe.Elderly individuals are at higher risk of chronic kidney disease(CKD),especially those with diabetes.Several studies found that the estimated glomerular filtration rate(eGFR)determined using creatinine-based equations was not as accurate as that determined using cystatin C-based equations.Cystatin C-based equations may be beneficial in elderly patients with an age-associated decline in kidney function.Early determination of eGFR decline and associated factors would aid in appropriate interventions to improve kidney function in elderly patients with diabetes.AIM To determine the utility of cystatin C-based equations in early detection of eGFR decline and to explore factors associated with eGFR decline in elderly patients with diabetes.METHODS This cross-sectional study included 93 participants aged≥60 years evaluated in Can Tho University of Medicine and Pharmacy Hospital between October 2022 and July 2023,including 47 and 46 participants with and without diabetes respectively,according to the American Diabetes Association criteria for diabetes.The kappa coefficient,Student’s t,Mann-Whitney,χ2,Pearson’s correlation,multivariate logistic regression,and multiple linear regression analyses were employed.RESULTS The eGFRs were lower with the cystatin C-based equations than with the creatinine-based equations.Good agreement was found between the Modification of Diet in Renal Disease(MDRD)and CKD Epidemiology Collaboration(CKD-EPI)2021 creatinine-cystatin C equations(kappa=0.66).In the diabetes group,30%of the participants had low eGFR.Both plasma glucose and glycated hemoglobin were associated with an increased risk of eGFR decline(P<0.05)and negatively correlated with eGFR(P=0.001).By multivariate logistic regression,total cholesterol,and exercise were independently associated with low eGFR.By multiple linear regression,higher plasma glucose levels were correlated with lower eGFR(P=0.026,r=-0.366).CONCLUSION Cystatin C-based equ

关 键 词：Cystatin C Estimated glomerular filtration rate ELDERLY DIABETES NEPHROLOGY Kidney function 

分 类 号：R692[医药卫生—泌尿科学] R587.1[医药卫生—外科学]