Beyond statistical significance:Embracing minimal clinically important difference for better patient care  

作　　者：Naveen Jeyaraman Madhan Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Sathish Muthu 

机构地区：[1]Department of Orthopaedics,ACS Medical College and Hospital,Dr MGR Educational and Research Institute,Chennai 600077,Tamil Nadu,India [2]Department of Research Methods,Orthopaedic Research Group,Coimbatore 641045,Tamil Nadu,India [3]Department of Orthopaedics,Government Medical College,Omandurar Government Estate,Chennai 600002,Tamil Nadu,India [4]Department of Biotechnology,Faculty of Engineering,Karpagam Academy of Higher Education,Coimbatore 641021,Tamil Nadu,India [5]Department of Orthopaedics,Government Medical College,Karur 639004,Tamil Nadu,India

出　　处：《World Journal of Methodology》2025年第1期33-41,共9页世界方法学杂志（英文）

摘　　要：The minimal clinically important difference(MCID)represents a pivotal metric in bridging the gap between statistical significance and clinical relevance,addressing the direct impact of medical interventions from the patient's perspective.This comprehensive review analyzes the evolution,applications,and challenges of MCID across medical specialties,emphasizing its necessity in ensuring that clinical outcomes not only demonstrate statistical significance but also offer genuine clinical utility that aligns with patient expectations and needs.We discuss the evolution of MCID since its inception in the 1980s,its current applications across various medical specialties,and the methodologies used in its calculation,highlighting both anchor-based and distribution-based approaches.Furthermore,the paper delves into the challenges associated with the application of MCID,such as methodological variability and the interpretation difficulties that arise in clinical settings.Recommendations for the future include standardizing MCID calculation methods,enhancing patient involvement in setting MCID thresholds,and extending research to incorporate diverse global perspectives.These steps are critical to refining the role of MCID in patient-centered healthcare,addressing existing gaps in methodology and interpretation,and ensuring that medical interventions lead to significant,patient-perceived improvements.

关 键 词：Minimal clinically important difference Patient-centered care Clinical relevance Global health 

分 类 号：R47[医药卫生—护理学]