超快生物光子学(特邀)  

Ultrafast Biophotonics(Invited)

作　　者：张宏飞 施可彬[1,2,3] Zhang Hongfei;Shi Kebin(State Key Laboratory of Artificial Microstructure and Mesoscopic Physics,School of Physics,Peking University,Beijing 100871,China;Frontiers Science Center for Nano-Optoelectronics,Peking University,Beijing 100871,China;Collaborative Innovation Center of Extreme Optics,Shanxi University,Taiyuan 030006,Shanxi,China)

机构地区：[1]北京大学物理学院人工微结构和介观物理国家重点实验室,北京100871 [2]北京大学物理学院纳光电子前沿科学中心,北京100871 [3]山西大学极端光学协同创新中心,山西太原030006

出　　处：《光学学报》2024年第17期134-148,共15页Acta Optica Sinica

基　　金：国家重点研发计划(2022YFC3401100,2022YFF0712500);国家自然科学基金(92150301)。

摘　　要：讨论了超快生物光子学在生物体系中的应用及发展。重点介绍了超快光学技术如何被应用于探测生物体系中发生在皮秒至飞秒时间尺度上的重要过程,通过结合先进的显微成像技术,超快测量方法不仅实现了高时间分辨率,还可以实现高空间分辨率,这使得实时观察生物分子在超快时间尺度上的动态行为成为可能,对深入理解生物分子的功能和机制至关重要。从超快时间分辨率、超高时空分辨率和超快非线性光谱技术三个方面介绍了超快探测方法与生物光子学的交叉应用。Significance The significance of ultrafast biophotonics lies in its ability to provide novel tools for exploring complex dynamic processes in living systems.Its extremely short timescales and high-resolution imaging capabilities enhance our understanding of the nature of life and drive advances in biomedicine and interdisciplinary integration.Ultrafast time-resolved technology captures transient changes in biomolecules and cells on femtosecond to picosecond timescales,which are challenging to observe under conventional conditions.Through ultrafast spectroscopy,time-resolved imaging,and related techniques,we can monitor critical events such as photophysical processes,energy transfer,and charge separation in real time,revealing the microscopic mechanisms of life activities.This understanding is crucial for comprehending the fundamental principles of living systems and exploring the molecular basis of disease development.Ultrafast biophotonics holds great promise in biomedicine.For example,in cancer diagnosis and treatment,ultrafast spectroscopy technology accurately distinguishes between the optical characteristics of normal cells and cancer cells,providing a reliable basis for early cancer detection.This technology helps to precisely identify tumor boundaries,improving surgical accuracy and success rates.It also enables real-time monitoring of drug distribution and metabolism in the body,supporting tailored treatment approaches.In drug development,ultrafast biophotonics detects structural changes in biomolecules and intermolecular interactions,which is critical for designing safer and more effective drugs.This technology also accelerates drug screening,improving the efficiency of research and development.In addition,ultrafast biophotonics offers a new perspective for biological research by enabling real-time observation of molecular-level changes during biological processes.This deeper understanding of chemical reactions and metabolic processes within organisms helps unravel mysteries in the life sciences and prom

关 键 词：超快探测 生物超快过程 超分辨成像 超快非线性光谱技术 

分 类 号：O437[机械工程—光学工程]