光学相干层析血管造影技术原理及其临床定量分析  

Principle and Clinical Quantitative Analysis of Optical Coherence Tomography Angiography

作　　者：王迪 张婷 梁姗姗 张军 Wang Di;Zhang Ting;Liang Shanshan;Zhang Jun(School of Life and Environmental Science,Guilin University of Electronic Science and Technology,Guilin 541004,Guangxi,China;National Innovation Center for Advanced Medical Devices,Shenzhen 518083,Guangdong,China)

机构地区：[1]桂林电子科技大学生命与环境科学学院,广西桂林541004 [2]国家高性能医疗器械创新中心,广东深圳518083

出　　处：《激光与光电子学进展》2024年第18期16-27,共12页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(61975246);广西自然科学基金(2022GXNSFDA080007);深圳市自然科学基金(JCYJ20220818103212026);深圳市科技技术攻关重点项目(JSGG20220831110400001)。

摘　　要：光学相干层析血管造影术(OCTA)以光学相干层析(OCT)技术为基础,是一种使用流动的红细胞作为内在造影剂的血管造影方法,具有高分辨率、高灵敏度以及非侵入性的优势。利用流动的红细胞与静态组织在OCT信号上的幅值与相位差异,可实现对视网膜血管网的三维造影。根据血管网的复杂性与形貌扭曲程度,设有血管密度指数、血管直径指数、血管周长指数、血管复杂指数等指标应用于糖尿病视网膜病变(DR)、静脉阻塞(VO)等眼病的筛查,在临床治疗中表现卓越。对OCTA的发展、算法的基本原理以及临床定量指标进行了概述,并简述了几种OCTA方法在标准定量指标上的对比。Optical coherence tomography angiography(OCTA),derived from optical coherence tomography(OCT)technology,is a vascular imaging approach that leverages flowing red blood cells as an intrinsic contrast agent.It has key advantages,including high resolution,sensitivity,and noninvasiveness.By discerning the amplitude and phase variances within OCT signals between flowing red blood cells and stationary tissue,OCTA enables 3D imaging of the retinal vascular network.Leveraging vascular density,diameter,perimeter,and complexity indices,OCTA is a screening tool for ocular pathologies such as diabetic retinopathy(DR)and venous occlusion(VO),exhibiting notable efficacy in clinical interventions.This article provides an overview of the evolution of OCTA,elucidates its algorithmic fundamentals,delineates clinical quantitative metrics,and briefly evaluates the comparison between various OCTA methods and standard quantitative indicators.

关 键 词：医用光学 光学相干层析成像 光学相干层析血管造影 临床定量指标 

分 类 号：R318.51[医药卫生—生物医学工程]