HIV-1耐药检测技术进展  

Advances in HIV-1 resistance detection technology

作　　者：沈奎灵 闫会敏 李林[1] 李韩平 SHEN Kuiling;YAN huimin;LI Lin;LI Hanping(Institute of Microbiology and Epidemiology,Institute of Military Medicine,Academy of Military Sciences,National Key Laboratory of Pathogenic Microbial Biosafety,Beijing 100071,China;School of Public Health,Hebei Medical University,Shijiazhuang 050017,China;Clinical Research Center,the Fifth Hospital of Shijiazhuang,Shijiazhuang 050021,China)

机构地区：[1]军事科学院军事医学研究院病原微生物生物安全全国重点实验室,北京100071 [2]河北医科大学公共卫生学院,石家庄050017 [3]石家庄市第五医院临床医学研究中心,石家庄050021

出　　处：《广西医科大学学报》2024年第10期1353-1359,共7页Journal of Guangxi Medical University

基　　金：国家重点研发计划项目(No.2022YFC2304900,No.2022YFC2304903);国家自然科学基金项目(No.82173583)。

摘　　要：艾滋病病毒已在全球肆虐40多年,对全球公共卫生造成极大压力,时至今日艾滋病仍然是全球公共卫生面临的一道医学难题。高效联合抗病毒疗法(HAART)是艾滋病治疗的首选方案,已为众多艾滋病患者/人类免疫缺陷病毒(HIV)感染者带来巨大福祉,并为减缓艾滋病病毒的进一步传播发挥了很大作用。但随着这一方案的全面推广与应用,HIV-1耐药性也日益突出。HIV-1耐药性是影响临床抗病毒治疗效果的主要原因之一,因此进行HIV-1耐药性检测,对抗病毒药物的优化与选择、降低传播性耐药发生与防控十分重要。HIV-1耐药检测方法众多,因应用场景不同而方法各异,本文汇总国内外众多文献资料,就HIV-1耐药检测方法进行综述。HIV has ravaged the world for more than forty years,causing great pressure on global public health.Today,AIDS is still a medical challenge for global public health.Highly active anti-retroviral therapy(HAART)is the preferred option for AIDS treatment.It has brought well-being to many people living with HIV,and has played a great role in slowing the further spread of HIV.However,with the comprehensive application of this therapy program,HIV-1 drug resistance has also become increasingly prominent.HIV-1 drug resistance is one of the main causes affecting the efficacy of clinical antiviral therapy.Therefore,it is very important to carry out HIV-1 drug resistance testing,optimize and select antiviral drugs,reduce the occurrence of transmitted resistance,and prevent and control them.HIV-1 resistance testing methods are numerous and various depending on the application scenarios.This paper summarizes many literatures around the world and comprehensively discusses HIV-1 drug resistance testing methods.

关 键 词：艾滋病 HIV-1耐药检测 基因型耐药检测 表型耐药检测 

分 类 号：R512.91[医药卫生—内科学]