伴自发性眼震与摇头眼震患者扫视波特征的自动量化分析  

Automated quantitative analysis of saccadic characteristics in patients with spontaneous and head-shaking nystagmus

作　　者：杜一 刘兴健 王郁 徐正燕 任丽丽 吴子明 DU Yi;LIU Xingjian;WANG Yu;XU Zhengyan;REN Lili;WU Ziming(The First Medical Center of the Chinese PLA General Hospital,Beijing 100853,China;National Key Laboratory of Hearing and Balance,Beijing 100853,China;National Clinical Research Center for Otolaryngology Disease,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第一医学中心,北京100853 [2]听觉与平衡觉全国重点实验室,北京100853 [3]国家耳鼻咽喉疾病临床医学研究中心,北京100853

出　　处：《广西医科大学学报》2024年第10期1378-1383,共6页Journal of Guangxi Medical University

摘　　要：目的:通过开发一款新的量化评估软件,分析自发性眼震(SN)和摇头眼震(HSN)患者的扫视波参数,以揭示前庭功能障碍患者的扫视波特征及其在不同代偿状态下的变化。方法:回顾性分析2023年9月至2024年6月在中国人民解放军总医院第一医学中心眩晕诊疗中心就诊患者的临床数据,采用自主开发的Saccades All in One(v1.0)软件处理视频头脉冲测试(vHIT)的原始数据,对SN组、HSN组和无眼震(None)组患者的扫视波参数进行分析。结果:SN组和HSN组患侧在第一和第二扫视波的数量、幅度和增益均显著高于健侧,且随代偿进展,受累侧的扫视波数量和幅度逐渐下降,到达时间提前,而健侧变化不明显。统计分析进一步证实了3组间扫视波参数存在显著差异,尤其在扫视波的数量和幅度方面。结论:通过本研究开发的量化工具能有效评估并区分代偿与未代偿状态下的扫视波特征,有助于前庭功能障碍患者的诊断与治疗。Objective:To explore the saccadic wave parameters of patients with spontaneous nystagmus(SN)and head-shaking nystagmus(HSN)by developing a new quantitative assessment software,so as to reveal the saccadic characteristics and variations in patients with vestibular dysfunction across different compensatory states.Methods:A retrospective analysis was conducted on clinical data of patients from the Dizziness Treatment Center of the First Medical Center of the Chinese PLA General Hospital between September 2023 and June 2024.The“Saccades All in One(v1.0)”software,developed in-house,was used to process the raw data from the video head impulse test(vHIT).Detailed analyses of saccadic wave parameters were performed for patients in the SN,HSN,and non-nystagmus(None)groups.Results:In the SN and HSN groups,the affected side showed significantly higher counts,amplitudes,and gains in the first and second saccadic waves compared to the unaffected side.With the progression of compensation,the number and amplitude of saccades on the affected side gradually decreased,and their latencies were earlier,whereas changes on the unaffected side were not pronounced.Statistical analyses further confirmed significant differences in saccadic parameters among the three groups,especially in terms of saccades count and amplitude.Conclusion:The quantitative tool developed in this study effectively evaluates and distinguishes the characteristics of saccades in compensated and uncompensated states,thereby facilitating the diagnosis and treatment of patients with vestibular dysfunction.

关 键 词：自发性眼震 摇头眼震 扫视波 前庭功能评估 视频头脉冲测试 

分 类 号：R764[医药卫生—耳鼻咽喉科]