补益类中药治疗阿尔茨海默病作用及机制研究进展  

Research progress on the effects and mechanisms of tonifying traditional Chinese medicine in⁃gredients in the treatment of Alzheimer’s disease over the past five years

作　　者：兰太进 蒋琳 洪晓华 刘一名 郭宏伟[1,2] LAN Taijin;JIANG Lin;HONG Xiaohua;LIU Yiming;GUO Hongwei(Key Laboratory of Longevity and Aging related Diseases of Chinese Ministry of Education&Center for Translational Medicine,Guangxi Medical University,Nanning 530021,China;Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation&Guangxi Key Laboratory of component efficacy relationship of Traditional Chinese Medicine,Pharmaceutical College,Guangxi Medical University,Nanning 530021,China;School of Preclinical Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]长寿与老年相关疾病教育部重点实验室广西医科大学转化医学研究中心,南宁530021 [2]广西生物活性分子研究与评价重点实验室广西中药组效学重点研究室广西医科大学药学院,南宁530021 [3]广西中医药大学基础医学院,南宁530200

出　　处：《广西医科大学学报》2024年第10期1425-1432,共8页Journal of Guangxi Medical University

基　　金：中央引导地方科技发展资金专项(No.防科ZY20221502);广西医科大学高水平创新团队及杏湖学者计划。

摘　　要：随着人口老龄化的加剧,阿尔茨海默病(AD)患者数量持续攀升,然其确切发病机制尚未完全明确,现有药物仅能缓解症状而无法根治。中医将AD纳入“痴呆”等范畴,认为其病机与肾精亏虚密切相关,多采用补益肾精治法,并在实践中重用补益类中药。随着现代科学方法的引入,补益类中药治疗AD的作用机制正逐渐被揭示。本文系统性回顾了近年来补益类中药为主的中药复方、单味药及活性部位、活性成分在AD治疗中的研究进展,重点梳理和总结了其复杂的作用机制,包括降低淀粉样蛋白β(Aβ)/tau蛋白、神经细胞保护和神经炎症抑制等。尽管补益类中药在AD治疗研究中取得了显著进展,但其临床转化应用仍面临着诸多挑战,未来我们需要更加专注于药效明确的补益类中药,进一步明晰其活性成分,阐明分子机制网络,以促进临床转化应用;同时,对尚未充分研究的补益类中药进行系统活性评价与活性部位筛选,以期发现新的治疗靶点,为AD治疗提供更多选择。With the intensification of population aging,the number of patients with Alzheimer’s disease(AD)continues to rise.However,the exact pathogenesis of AD remains unclear,and existing drugs can only alleviate symptoms without providing a cure.Traditional Chinese medicine(TCM)holds that the pathogenesis of AD is closely related to kidney essence deficiency.Treatment often involves tonifying kidney essence,with frequent use of tonifying TCM ingredients in practice.With the introduction of modern scientific methods,the mechanisms of action of tonifying TCM ingredients in treating AD are gradually being revealed.This article systematically reviews the recent research progress on the use of TCM ingredients,including formulas,single ingredient,active parts and active ingredients in the treatment of AD,focusing on summarizing their complex mechanisms of action,including reducing Amyloid-beta(Aβ)/tau protein,neuroprotection and inhibition of neuroinflammation.Although significant progress has been made in the research on tonifying TCM ingredients for the treatment of AD,there are still many challenges in their clinical translation and application.In the future,it is necessary to further focus on tonifying TCM ingredients with clear efficacy,delve into their active ingredients,and elucidate their molecular mechanism networks to facilitate clinical translation and application.Meanwhile,systematic activity evaluation and screening of active parts are carried out for the understudied tonifying TCM ingredients in order to discover new therapeutic targets and provide more options for the treatment of AD.

关 键 词：阿尔茨海默病 补益类中药 作用机制 研究进展 

分 类 号：R277.7[医药卫生—中医学]