中药治疗神经免疫炎性疾病作用机制的研究进展  

Research progress on the mechanism of Chinese medicine in the treatment of neuroimmune inflammatory diseases

作　　者：崔兵兵[1] 李季 朱娟娟 聂金娥 孙丹丹[2] 杨春林 杨颖[1] CUI Bingbing;LI Ji;ZHU Juanjuan;NIE Jin′e;SUN Dandan;YANG Chunlin;YANG Ying(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Shandong Research Academy of Traditional Chinese Medicine,Jinan 250014,China;The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan 250014,China)

机构地区：[1]山东中医药大学附属医院,山东济南250014 [2]山东省中医药研究院,山东济南250014 [3]山东第一医科大学第一附属医院<山东省千佛山医院>,山东济南250014

出　　处：《药学研究》2024年第10期995-1000,共6页Journal of Pharmaceutical Research

基　　金：山东省自然科学基金项目(No.ZR2021QH019)。

摘　　要：神经免疫炎症贯穿神经自身免疫和神经退行性疾病等多种中枢神经系统疾病的发病过程。神经免疫炎症具有双向调节作用,在正常生理情况下,可以消除致病因子保护神经元免受伤害,促进其恢复,然而慢性炎症诱导的细胞毒性和过度的炎症反应会加重神经元的损害。目前临床尚无有效治疗此类疾病的药物,多以改善症状为主,无法消除病因且副作用较大。近年来中药因安全性较高、作用温和、副作用小等优势被广泛研究,本文针对中药治疗此类疾病的有关机理整理综述。Neuroimmune inflammation runs through the pathogenesis of many central nervous system diseases such as neuroautoimmune and neurodegenerative diseases.Neuroimmune inflammation has a bidirectional regulatory effect.Under normal physiological conditions,it can eliminate pathogenic factors to protect neurons from injury and promote their recovery.However,chronic inflammatory induced cytotoxicity and excessive inflammatory response will aggravate the damage of neurons.At present,there is no effective drug to treat this kind of disease in clinic,mainly to improve the symptoms,unable to eliminate the cause and side effects.In recent years,traditional Chinese medicine has been widely studied for its advantages of high safety,mild action and few side effects.This article summarizes the relevant mechanisms of traditional Chinese medicine in the treatment of such diseases.

关 键 词：中药 神经免疫疾病 神经退行性疾病 作用机理 

分 类 号：R285[医药卫生—中药学]