废用性骨质疏松治疗回顾及α-酮戊二酸对废用性骨质疏松治疗展望  

Review of the treatment of disuse osteoporosis and prospects of alpha ketoglutarate in the treatment of disuse osteoporosis

作　　者：周江 黄晨 徐伟 李想[2] 陈紫豪 廖冬发 ZHOU Jiang;HUANG Chen;XU Wei;LI Xiang;CHEN Zihao;LIAO Dongfa(Department of Orthopedics,the General Hospital of the Western Theater Command of the Chinese People’s Liberation Army,Chengdu 610083,China;Chengdu Medical College,Chengdu 611130,China)

机构地区：[1]中国人民解放军西部战区总医院骨科,四川成都610083 [2]成都医学院,四川成都611130

出　　处：《中国骨质疏松杂志》2024年第11期1673-1677,共5页Chinese Journal of Osteoporosis

基　　金：军委后勤保障部资助项目(19BJZ11)。

摘　　要：废用性骨质疏松症是指由于局部卸载或全身废用而导致的骨量丢失。骨骼在缺失负荷及机械应力刺激下,破骨效应大于成骨效应,从而出现骨量丢失致骨质疏松。α-酮戊二酸不仅是骨骼肌的一种代谢产物,同时也是细胞信号分子,其具有促进成骨作用,并抑制破骨作用。且α-酮戊二酸有促进骨骼肌生长的作用,能更好使肢体恢复负荷及机械刺激。通过之前学者研究并总结得出α-酮戊二酸在治疗废用性骨质疏松上有较好前景。该文旨在对废用性骨质疏松病因机制目前治疗方式及α-酮戊二酸在影响骨代谢机制进行论述,并展望α-酮戊二酸对废用性骨质疏松治疗。Obstructive osteoporosis refers to the loss of bone mass caused by local unloading or systemic disuse.Under the lack of load and mechanical stress stimulation,the bone breaking effect is greater than the osteogenic effect,resultsing in bone loss and osteoporosis.Alpha ketoglutarate is not only a metabolite of skeletal muscle,but also a cellular signaling molecule that promotes osteogenesis and inhibits osteoclastogenesis.Andα-ketoglutarate has the effect of promoting skeletal muscle growth,which can better restore limb load and mechanical stimulation.Through previous research and summarization by scholars,it has been concluded that alpha ketoglutarate has good prospects in the treatment of disuse osteoporosis.The purpose of this article is to discuss the etiology and current treatment method of disuse osteoporosis,as well as the impact of alpha ketoglutarate on bone metabolism,and to provide prospects for the treatment of disuse osteoporosis with alpha ketoglutarate.

关 键 词：Α-酮戊二酸 废用性骨质疏松 骨代谢 

分 类 号：R589.5[医药卫生—内分泌]