线粒体稳态和铁死亡在骨代谢紊乱中的作用机制  

The mechanism of mitochondrial homeostasis and ferroptosis in bone metabolic disorders

作　　者：胡云浩 凡一诺 陈志文 高张 卢鸿铎 卫杨文祥 江梦钰 李梓媛 方汉军 黄泽青 刘予豪 周驰[4,5] 何伟 陈镇秋[4] HU Yunhao;FAN Yinuo;CHEN Zhiwen;GAO Zhang;LU Hongduo;WEI Yangwenxiang;JIANG Mengyu;LI Ziyuan;FANG Hanjun;HUANG Zeqing;LIU Yuhao;ZHOU Chi;HE Wei;CHEN Zhenqiu(The first Clinical Medical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510499,China;Lingnan Medical Research Center of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510388,China;The third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510378,China;The first Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;Maoming Hospital of Guangzhou University of Traditional Chinese Medicine(Maoming Hospital of Traditional Chinese Medicine),Maoming 525022,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510499 [2]广州中医药大学岭南医学研究中心,广东广州510388 [3]广州中医药大学第三附属医院,广东广州510378 [4]广州中医药大学第一附属医院,广东广州510405 [5]广州中医药大学茂名医院(茂名市中医院),广东茂名525022

出　　处：《中国骨质疏松杂志》2024年第11期1705-1710,1716,共7页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(82374475);国家自然科学基金青年科学基金项目(82205138)。

摘　　要：骨疾病如骨质疏松、骨关节炎、风湿性关节炎等是长期困扰人们的一类疾病。其发病机制可能是多因素的,例如遗传、生活环境、药物作用等,人们普遍认为,骨代谢紊乱是骨疾病发生机制中的重要一环。随着研究的深入,人们发现铁死亡与线粒体稳态在调节成骨、破骨、软骨细胞的增殖、分化和功能以及骨相关疾病中起着至关重要的作用。该文通过总结目前关于线粒体稳态和铁死亡及其在骨代谢紊乱中的作用机制,并深入阐述三者之间关系,旨在探寻线粒体稳态和铁死亡在治疗骨代谢紊乱所致疾病潜力和新的研究方向。Bone diseases such as osteoporosis,osteoarthritis,and rheumatoid arthritis are a class of diseases that have long plagued people.Its pathogenesis may be multi-factorial,such as genetics,living environment,and drug effects.It is generally believed that bone metabolic disorders are an important part of the pathogenesis of bone diseases.With the deepening of research,it has been found that ferroptosis and mitochondrial homeostasis play a crucial role in regulating osteogenesis,osteoclasts,chondrocyte proliferation,differentiation and function,and bone-related diseases.This article will summarize the current research on mitochondrial homeostasis and ferroptosis and their mechanisms of action in bone metabolism disorders,and elaborate on the relationship between the three.The aim is to explore the potential and new research directions of mitochondrial homeostasis and ferroptosis in the treatment of diseases caused by bone metabolic disorders.

关 键 词：骨代谢紊乱 线粒体稳态 铁死亡 成骨细胞 破骨细胞 

分 类 号：R589[医药卫生—内分泌]