气体信号分子硫化氢防治骨质疏松的作用与机制  

The role and mechanism of hydrogen sulfide as a gasotransmitter in preventing and treating osteoporosis

作　　者：张康华 廖锋[1] ZHANG Kanghua;LIAO Feng(Department of Orthopedics,Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China;School of Medicine,University of Electronic Science and Technology of China,Chengdu 611731,China)

机构地区：[1]四川省医学科学院·四川省人民医院(电子科技大学附属医院)骨科,四川成都610072 [2]电子科技大学医学院,四川成都611731

出　　处：《中国骨质疏松杂志》2024年第11期1711-1716,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金青年科学基金项目(82000835)。

摘　　要：作为一种气体信号分子,近年来硫化氢(H_(2)S)防治骨质疏松的作用得到证实,其病理生理机制也陆续被阐明。H_(2)S能通过拮抗氧化应激和炎症反应、促进血管生成、调节肠道菌群和钙磷代谢,促进骨形成、抑制骨吸收,进而防治多种类型的骨质疏松,如绝经后骨质疏松、糖皮质激素或高同型半胱氨酸引发的骨质疏松。本文对现有研究进行总结,为进一步探索骨质疏松症的发病机制和治疗方案提供新思路。As a gasotransmitter,the role of hydrogen sulfide(H_(2)S)in preventing and treating osteoporosis has been confirmed in recent years,and its pathophysiological mechanism is gradually elucidated.H_(2)S counteracts oxidative stress and inflammatory reactions,promotes angiogenesis,regulates intestinal flora and calcium-phosphorus metabolism,thus enhancing bone formation and inhibiting bone resorption,further preventing and treating various types of osteoporosis,such as postmenopausal osteoporosis and,glucocorticoid,or homocysteine-induced osteoporosis.This article summarizes the existing research to provide new insights for further understanding the pathogenesis and treatment of osteoporosis.

关 键 词：硫化氢 骨质疏松 氧化应激 炎症反应 血管生成 肠道菌群紊乱 钙磷代谢 

分 类 号：R336[医药卫生—人体生理学] R681[医药卫生—基础医学]