Family functioning mediation in tic severity and quality of life for children with Tourette syndrome  

作　　者：Shu-Jin Hu Ying Li Qing-Hao Yang Kai Yang Jin-Hyun Jun Yong-Hua Cui Tian-Yuan Lei 

机构地区：[1]Department of Psychiatry,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China

出　　处：《World Journal of Psychiatry》2024年第11期1641-1651,共11页世界精神病学杂志（英文）

基　　金：Supported by the National Natural Science Foundation of China,No.82171538;the Beijing High Level Public Health Technology Talent Construction Project,No.Discipline Leader-01-07.

摘　　要：BACKGROUND Tourette syndrome(TS)is recognized as a neurodevelopmental disorder profoundly influenced by familial factors,particularly family functioning.However,the relationship among family functioning,tic severity,and quality of life in individuals with TS during childhood and adolescence remains unclear.We hypothesized that family functioning plays a role in the association between the severity of TS and quality of life in children.AIM To determine the role of family functioning in the relationship between TS severity and quality of life.METHODS This study enrolled 139 children(male/female=113/26)with TS.We assessed tic severity using the Yale Global Tic Severity Scale,quality of life via the Tourette Syndrome Quality of Life Scale,and family functioning through the Family Assessment Device.Our analysis focused on correlating these measures and exploring the mediating role of family functioning in the relationship between tic severity and quality of life.Additionally,we examined if this mediating effect varied by gender or the presence of comorbidity.RESULTS We found that family communication dysfunction had a significant mediating effect between tic severity and both psychological symptoms(indirect effect:Β=0.0038,95%confidence interval:0.0006-0.0082)as well as physical and activities of daily living impairment(indirect effect:Β=0.0029,95%confidence interval:0.0004-0.0065).For vocal tic severity,this mediation was found to be even more pronounced.Additionally,in male participants and those without attention deficit hyperactivity disorder,the mediating effect of family communication dysfunction was still evident.CONCLUSION Our study highlights the impact of family functioning on the tic severity and the quality of life in children.This relationship is influenced by gender and comorbid conditions like attention deficit hyperactivity disorder.

关 键 词：Tourette syndrome Family functioning Quality of life Tic severity Children and adolescents 

分 类 号：R72[医药卫生—儿科]