米索前列醇片致重度过敏性休克1例分析  

One case of severe allergic shock caused by misoprostol tablets

作　　者：姜仁俊 覃树勇 王媛 罗穗 JIANG Renjun;QIN Shuyong;WANG Yuan;LUO Sui(Department of Pharmacy,Chongqing Dazu District Maternal and Child Health Hospital,Chongqing 402360,China;Department of Gynaecology,Chongqing Dazu District Maternal and Child Health Hospital,Chongqing 402360,China)

机构地区：[1]重庆市大足区妇幼保健院药剂科,重庆402360 [2]重庆市大足区妇幼保健院妇科,重庆402360

出　　处：《中国药物警戒》2024年第10期1175-1177,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨米索前列醇片致过敏性休克不良反应及其不同给药途径的影响,为临床安全使用提供参考。方法分析1例29岁女性药物流产患者舌下含化米索前列醇片(400μg)后出现过敏性休克并致心搏骤停的可能原因,检索同类文献病例,提出用药建议。结果患者服用米索前列醇片后出现过敏性休克、心搏骤停,分析相关用药和给药时间,考虑疑似为米索前列醇引起的严重药品不良反应。梳理相关文献和病例,提示不同给药途径皆有可能发生不良反应。结论米索前列醇片可能会增加心搏骤停不良反应的风险,临床用药时需警惕,并做好用药教育。Objective To study one case of allergic shock caused by misoprostol tablets and the effects of different administration routes so as to provide references for safe use.Methods The clinical data of a 29-year-old patient with medical abortion due to 400μg of misoprostol tablets sublingually was reviewed and the cause of allergic shock leading to cardiac arrest was analyzed.Medications were recommended after related literature was consulted.Results Allergic shock and cardiac arrest occurred in the patient who had received misoprostol tablets sublingually.The analysis of medications time of delivery pointed to severe adverse drug reactions(ADR).By analyzing relevant literature and cases,it was found that ADR might occur through different administration routes.Conclusion Misoprostol tablets may increase the risk of cardiac arrest,so clinical vigilance is required.

关 键 词：米索前列醇 药物流产 过敏性休克 心搏骤停 前列腺素 药品不良反应 

分 类 号：R984[医药卫生—药品] R994.11[医药卫生—药学]