注射用克林霉素磷酸酯致神经肌肉阻滞1例分析  

One case of neuromuscular block caused by clindamycin phosphate for injection

作　　者：张皓 曹树刚[1] 贺军[1] 徐文安[1] 夏明武[1] ZHANG Hao;CAO Shugang;HE Jun;XU Wenan;XIA Mingwu(Department of Neurology,Hefei Second People’s Hospital,Hefei Anhui 230011,China)

机构地区：[1]合肥市第二人民医院神经内科,安徽合肥230011

出　　处：《中国药物警戒》2024年第10期1178-1180,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨注射用克林霉素磷酸酯致神经肌肉阻滞不良反应,为临床安全使用提供参考。方法结合相关文献,对1例51岁牙周脓肿患者应用注射用克林霉素磷酸酯后出现肌无力病例进行分析。结果患者使用替硝唑联合注射用克林霉素磷酸酯后出现肌无力,肌无力症状可能与注射用克林霉素磷酸酯有关,怀疑为注射用克林霉素磷酸酯导致的不良反应。经对症治疗后肌力基本恢复正常。结论临床发现肌无力症状时需考虑注射用克林霉素磷酸酯引起的可能性。对于合并使用神经肌肉阻滞药物的患者,注射用克林霉素磷酸酯应谨慎使用。Objective To investigate such adverse reactions as neuromuscular blockade caused by clindamycin phosphate for injection so as to provide references for clinical safe use.Methods Based on related literature,one case of myasthenia gravis in a 51-year-old patient with periodontal abscess after receiving clindamycin phosphate for injection was analyzed.Results The patient experienced muscle weakness after taking tinidazole and clindamycin phosphate for injection.The symptoms were considered to be adverse reactions related to clindamycin phosphate for injection.After symptomatic treatment,the patient's muscle strength was largely normalized.Conclusion In case of myasthenia gravis,the possibility of the symptoms being caused by clindamycin phosphate for injection should be considered.Clindamycin phosphate for injection should be used with caution in patients who are taking neuromuscular blocking drugs concurrently.

关 键 词：克林霉素 注射用 神经肌肉阻滞 肌无力 药品不良反应 

分 类 号：R978[医药卫生—药品] R994.11[医药卫生—药学]