壳聚糖及其衍生物促进伤口愈合的研究进展  

Research progress of chitosan and its derivatives in promoting wound healing

作　　者：姚训文 陈博 肖炜 谢文斌 桂蓦睿 龚震宇 YAO Xunwen;CHEN Bo;XIAO Wei;XIE Wenbin;GUI Morui;GONG Zhenyu(Burn Wound Repair Plastic Surgery/Medical Cosmetic Surgery,Affiliated Hospital of Guilin Medical University,Guilin 541001,China)

机构地区：[1]桂林医学院附属医院烧伤创面修复整形外科/医学美容外科,桂林541001

出　　处：《华夏医学》2024年第5期16-22,共7页Acta Medicinae Sinica

基　　金：教育部科技发展中心产学研创新基金项目(2021JB017);广西医疗卫生适宜技术开发与推广应用项目(S2023103);桂林市科学研究与技术开发计划项目(20220116-1,2020011204-2)。

摘　　要：近年来,为了促进伤口愈合,预防瘢痕增生一直是研究的热点和难题。创面愈合是由多种生长因子、炎症细胞、修复细胞共同参与的过程,是一个复杂且程序化的过程。为了针对这一创面修复的过程,诞生许多为了修复创面的新型合成敷料。天然聚合物壳聚糖是临床上新型合成敷料应用最广泛的原料之一,其制作成本低,有着资源的可再生性,在生物医学领域尤其在伤口敷料领域表现出良好的生物相容性和生物降解性,现在可以通过改性获得壳聚糖的衍生物,其衍生物在继承原本壳聚糖的优点之外,还具有更好的抗菌活性、生物相容性以及降解性。壳聚糖衍生物与不同种类的新型合成敷料结合,针对不同的创面提供良好的愈合环境,促进伤口的愈合。本文就以壳聚糖及其衍生物促进伤口愈合的研究进展进行综述。In recent years,preventing scar hyperplasia to promote wound healing has been a challenging and popular area of research.Wound healing is a complex,programmed process involving various growth factors,inflammatory cells,and repair cells.To enhance the wound repair process,new synthetic dressings have been developed,with natural polymer chitosan as one of the most widely used raw materials due to its low production cost and renewable resources.In the biomedical field,chitosan-based wound dressings exhibit good biocompatibility and biodegradability.Now,modified chitosan derivatives,which retain the benefits of the original while offering improved antibacterial activity,biocompatibility,and degradability,are available.Chitosan derivatives are combined with various types of new synthetic dressings to create an optimal healing environment for different wounds and promote wound healing.This paper discusses the development and application of new synthetic dressings made from chitosan derivatives for wound healing.

关 键 词：新型合成敷料 壳聚糖 壳聚糖衍生物 伤口愈合 

分 类 号：R641[医药卫生—外科学]