益气维血胶囊联合重组人促红细胞生成素对腹膜透析贫血的治疗作用  

Therapeutic effects of Yiqi Weixue capsules combined with recombinant human erythropoietin on peritoneal dialysis anemia

作　　者：丁元 沈春燕 张博 DING Yuan;SHEN Chunyan;ZHANG Bo(Department of Nephrology,Xinyang Central Hospital,Xinyang 464000,China)

机构地区：[1]信阳市中心医院肾病内科,信阳464000

出　　处：《华夏医学》2024年第5期173-178,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关联合共建项目(LHGJ20211096)。

摘　　要：目的探讨益气维血胶囊联合重组人促红细胞生成素(EPO)治疗腹膜透析贫血的效果及其临床应用价值。方法选取2022年12月至2023年12月信阳市中心医院诊收的104例腹膜透析贫血患者,采用随机法分为对照组和联合组,每组52例。对照组给予重组人EPO治疗,联合组给予益气维血胶囊联合重组人EPO治疗。比较两组临床疗效、中医证候积分、血红蛋白(Hb)、EPO、转铁蛋白饱和度(TSAT)、铁蛋白(SF)及不良反应。结果联合组治疗总有效率94.23%高于对照组78.85%,差异有统计学意义(P<0.05);治疗后,联合组中医证候积分低于对照组,Hb、EPO、TSAT、SF水平高于对照组(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论益气维血胶囊联合重组人EPO治疗腹膜透析性贫血,可改善贫血症状,调节铁代谢,提高治疗效果。Objective To investigate the effects and clinical application value of Yiqi Weixue capsules combined with recombinant human erythropoietin(EPO)in the treatment of anemia in peritoneal dialysis patients.Methods 104 patients with anemia due to peritoneal dialysis who were treated at Xinyang Central Hospital from December 2022 to December 2023 were selected and randomly divided into the control group and combined group using a random method,with 52 patients in each group.The control group were treated with recombinant human EPO,while the combined group were treated with Yiqi Weixue capsules in combination with recombinant human EPO.The clinical efficacy,TCM syndrome scores,hemoglobin(Hb),EPO,transferrin saturation(TSAT),ferritin(SF)and adverse reactions were compared between two groups.Results The total effective rate in the combined group was 94.23%higher than 78.85%in the control group,and the difference was statistically significant(P<0.05).After treatment,the score of TCM syndrome in the combined group was lower than that in the control group.The levels of Hb,EPO,TSAT,and SF in the combined group after treatment were higher than those in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Yiqi Weixue capsule combined with EPO in the treatment of peritoneal dialysis patients with anemia is effective,which improves the clinical symptoms and anemia status,regulates the iron metabolism and improves the treatment effect.

关 键 词：腹膜透析 贫血 益气维血胶囊 重组人促红细胞生成素 

分 类 号：R556[医药卫生—血液循环系统疾病]