铁死亡在子宫内膜异位症中的研究进展  

Study progress on ferroptosis in endometriosis

作　　者：李卓[1,2] 周华 曾薇薇[1] LI Zhuo;ZHOU Hua;ZENG Weiwei(Department of Gynecology,Affiliated Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 210213,China;Department of Traditional Chinese Medicine,Gaodong Community Health Service Center of Pudong New District,Shanghai 201208,China)

机构地区：[1]上海中医药大学附属曙光医院妇科,上海210213 [2]上海市浦东新区高东社区卫生服务中心中医科,上海201208

出　　处：《重庆医学》2024年第21期3318-3322,3328,共6页Chongqing Medical Journal

基　　金：国家自然科学基金项目(81574012,82004398);上海市海派中医流派传承人才培养项目(LPRC2017032)。

摘　　要：子宫内膜异位症(EMs)作为一种常见的慢性疾病影响近10%的育龄女性,可能造成不孕症等其他并发症,并且具有发展为恶性肿瘤的倾向。铁死亡是一种新发现的程序性细胞死亡,主要特征表现为细胞内游离二价铁过量介导芬顿反应,最终导致细胞膜脂质发生过氧化而引起细胞死亡。EMs病灶整体表现为铁死亡抵抗,与其铁超载和氧化应激有关,细胞内铁浓度的异常变化可能会导致活性氧的集聚及氧化还原稳态失衡,从而诱导铁死亡的发生。目前铁死亡对EMs的发病机制及造成的影响尚未完全明确,研究其生理病理学机制对其诊断和治疗至关重要,该文以铁死亡为切入点,将其与EMs发生、发展的研究进展进行综述,以期为EMs的发病机制、诊断及治疗提供新思路。Endometriosis(EMs)as a common chronic disease affects nearly 10%of childbearing age women,may cause other complications such as infertility,moreover has a tendency to develop malignant tumors.Ferroptosis is a newly discovered programmed cell death,its main characteristic is manifested by intracellular free ferrous excessively mediating Fenton reaction and eventually leads to lipid peroxidation in the cell membrane,thus causes the cell death.The overall manifestation of EMs lesions is iron death resistance,which is related with the iron overload and oxidative stress.The abnormal changes of intracellular iron concentration may lead to the accumulation of reactive oxygen and imbalance of redox homeostasis,thus leading to the occurrence of ferroptosis.At present,the pathogenesis and effect of ferroptosis on EMs are not completely clear,and the study on its physiological and pathological mechanism is very important for its diagnosis and treatment.This article reviews the research progress of the occurrence and development of EMs with ferroptosis as the s tarting point in order to provide the new ideas for the pathogenesis,diagnosis and treatment of EMs.

关 键 词：铁死亡 子宫内膜异位症 铁离子代谢 不孕 综述 

分 类 号：R711.6[医药卫生—妇产科学]