基于数据挖掘探讨中医药治疗围绝经期综合征的用药规律  

Research on the regularity of traditional Chinese medicine in the treatment of perimenopausal syndrome based on data mining

作　　者：李俊霖 马红[2] 韦敏[1] 吕晔[1,3] 肖珺 LI Junin;MA Hong;WEI Min;LYU Ye;XIAO Jun(Medicinal Plant Research Center,Institute of Botany,Jiangsu Province and Chinese Academy of Sciences,Nanjing 210014,Jiangsu,China;School of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China;Nuofanghua(Wuxi)Life Technology Co.Ltd.,Wuxi 214028,Jiangsu,China)

机构地区：[1]江苏省中国科学院植物研究所药用植物研究中心,江苏南京210014 [2]南京中医药大学中西医结合学院,江苏南京210023 [3]诺芳华(无锡)生命科技有限公司,江苏无锡214028

出　　处：《中国现代医生》2024年第31期64-67,84,共5页China Modern Doctor

摘　　要：目的探讨中医药治疗围绝经期综合征(perimenopausal syndrome,PMS)的用药规律。方法检索中国知网、万方数据和维普数据库2014年1月至2024年1月发表的关于中医药治疗PMS的临床研究文献,并对所有药物进行频次、性味、归经等分析,运用SPSS Modeler 18.0软件进行数据挖掘,确定核心药物组合并进行聚类分析。结果共纳入142篇文献,包含方剂142首,中药139味,用药频次总计1555次,其中使用频数≥20次的药物26味。药物功效以补虚药、清热药为主,药性以寒性为主,药味以甘味居多,多归于肝、肾、脾经。关联规则分析得到5个常用药对;聚类分析得到3个常用药物组方。结论PMS以肾虚为本,病机为肾阴不足、肝失疏泄、脾胃失养,治疗以补益肝肾、滋阴清热为主,辅以调和脏腑。Objective To explore the regularity of traditional Chinese medicine in the treatment of perimenopausal syndrome(PMS).Methods The clinical research literatures on the treatment of PMS with traditional Chinese medicine published from January 2014 to January 2024 was retrieved from CNKI,Wanfang Data and VIP database,and the frequency,taste and meridian tropism of all drugs were analyzed.SPSS Modeler 18.0 software was used for data mining to determine the core drug combination and cluster analysis.Results A total of 142 literatures were included,including 142 prescriptions and 139 traditional Chinese medicines.The total frequency of medication was 1555 times,of which 26 drugs were used more than 20 times.The efficacy of drugs was mainly tonic drugs and heat-clearing drugs.The medicinal properties were mainly cold,and the taste was mostly sweet,which was mostly attributed to the liver,kidney and spleen meridians.Five commonly used drug pairs were obtained by association rule analysis.Three commonly used drug prescriptions were obtained by cluster analysis.Conclusion PMS is based on kidney deficiency,the pathogenesis of kidney yin deficiency,liver dysfunction,spleen and stomach dysplasia,the treatment of tonifying liver and kidney,nourishing yin and clearing heat,supplemented by harmonizing viscera.

关 键 词：围绝经期综合征 中医药 数据挖掘 用药规律 

分 类 号：R271.116[医药卫生—中医妇科学]