Epstein-Barr virus positive post-transplant lymphoproliferative disorder with significantly decreased T-cell chimerism early after transplantation:A case report  

作　　者：Qing-Na Guo Hai-Sheng Liu Lin Li Dian-Ge Jin Ji-Min Shi Xiao-Yu Lai Li-Zhen Liu Yan-Min Zhao Jian Yu Yan-Yuan Li Fang-Quan Yu Zhe Gao Jiao Yan He Huang Yi Luo Yi-Shan Ye 

机构地区：[1]Bone Marrow Transplantation Center,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang Province,China [2]Department of Hematology,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050035,Hebei Province,China [3]Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou 310003,Zhejiang Province,China [4]Department of Pathology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang Province,China [5]Department of Hematology,Jinhua People’s Hospital,Jinhua 321000,Zhejiang Province,China

出　　处：《World Journal of Radiology》2024年第10期600-607,共8页世界放射学杂志（英文）

摘　　要：BACKGROUND Post-transplant lymphoproliferative disorder(PTLD)is a rare but highly fatal complication occurring after allogeneic hematopoietic cell transplantation(allo-HCT)or solid organ transplantation(SOT).Unlike SOT,PTLD after allo-HCT usually originates from the donor and is rarely accompanied by a loss of donor chimerism.CASE SUMMARY We report a case of Epstein-Barr virus positive PTLD manifesting as diffuse large B-cell lymphoma(DLBCL)with significantly decreased T-cell chimerism early after allo-HCT.A 30-year-old patient with acute myeloid leukemia underwent unrelated allo-HCT after first complete remission.Nearly 3 mo after transplantation,the patient developed cervical lymph node enlargement and gastric lesions,both of which were pathologically suggestive of DLBCL.Meanwhile,the patient experienced a significant and persistent decrease in T-cell chimerism.A partial remission was achieved after chemotherapy with single agent rituximab and subsequent R-CHOP combined chemotherapy.CONCLUSION The loss of T-cell chimerism and the concomitant T-cell insufficiency may be the cause of PTLD in this patient.

关 键 词：Post-transplant lymphoproliferative disorder T-cell chimerism Epstein-Barr virus T cell function Case report 

分 类 号：R392[医药卫生—免疫学]