从“虚毒”探讨炎症性肠病“炎癌转化”  

Discussion on"inflammation-cancer transformation"of inflammatory bowel disease from the perspective of"deficiency-toxin"theory

作　　者：魏秀楠 梁峻尉[2] 孙大娟[2] 张苗苗 迟莉丽[2] WEI Xiunan;LIANG Junwei;SUN Dajuan;ZHANG Miaomiao;CHI Lili(First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学附属医院

出　　处：《北京中医药大学学报》2024年第10期1349-1354,共6页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(No.81673969,No.82205057);济南市科技计划项目(No.202134024);山东中医药大学青年科研创新团队。

摘　　要：“虚”“毒”作为中医理论的重要概念,自《黄帝内经》以来不断丰富发展。本文通过追溯、梳理“虚”与“毒”,归纳二者关系,并结合临证实践,分析阐释其基本内涵,并探讨其外延。“虚毒”学说有静态与动态两层含义,既涵盖人体正气虚馁、邪毒亢盛的病理状态,又指代“虚”与“毒”相互推进的病理演变过程。基于“虚毒”学说的内涵及动态病机观点,该学说可适用于传染性疾病及虚损性疾病的防治,炎症性肠病“炎癌转化”亦在其列。本文以炎症性肠病为例,结合其西医学背景,阐述炎症性肠病“炎癌转化”的病机及治法,提供“虚毒”学说指导临床科研的范式。As essential concepts of the traditional Chinese medicine theory,"deficiency"and"toxin"have been enriched and developed continuously since Huangdi Neijing.By tracing back and combing"deficiency"and"toxin",this paper sums up their relationship,analyzes and explains their basic connotation,and discusses their extension.The"deficiency-toxin"theory has two meanings:it covers the pathological state of the human body with deficiency of vital qi and excess of pathogenic toxin,and it also refers to the pathological evolutionary process in which"deficiency"and"toxin"promote each other.Based on the connotation and dynamic pathogenesis of the"deficiency-toxin"theory,it is pointed out that this theory can be applied to the prevention and treatment of infectious diseases and chronic debilitating diseases,including the"inflammation-cancer transformation"of inflammatory bowel disease.Taking inflammatory bowel disease as an example and combining its Western medical background,this paper expounds on the pathogenesis and treatment of the"inflammation-cancer transformation"of inflammatory bowel disease,and provides a paradigm of"deficiency-toxin"theory guiding clinical research.

关 键 词：虚毒 炎癌转化 炎症性肠病 

分 类 号：R259[医药卫生—中西医结合]