A state-of-the-art review on recent advances in the fabrication and characteristics of magnesium-based alloys in biomedical applications  

作　　者：Fatemeh Zahra Akbarzadeh Masoud Sarraf Erfan Rezvani Ghomi Vishnu Vijay Kumar Mojtaba Salehi Seeram Ramakrishna Sungchul Bae 

机构地区：[1]Department of Materials Engineering,Babol Noshirvani University of Technology,Shariati Ave.,Babol 47148-71167,Iran [2]Deputy Vice Chancellor’s Office(Research&Innovation),University of Malaya,Kuala Lumpur 50603,Malaysia [3]Center of Advanced Manufacturing and Material Processing,Department of Mechanical Engineering,Faculty of Engineering University of Malaya,Kuala Lumpur 50603,Malaysia [4]Department of Mechanical Engineering,Faculty of Engineering,University of Malaya,Kuala Lumpur 50603,Malaysia [5]Center for Nanotechnology and Sustainability,Department of Mechanical Engineering,National University of Singapore,Singapore 117581,Singapore [6]Lee Kong Chian School of Medicine,Nanyang Technological University Singapore,Clinical Sciences Building,11 Mandalay Road,Singapore 308232,Singapore [7]Structural Engineering,Division of Engineering,New York University Abu Dhabi(NYUAD),PO Box 129188 Abu Dhabi,United Arab Emirates [8]International Institute of Aerospace Engineering&Management,JAIN(Deemed-to-be-university),JGI global campus,Bangalore,562112,India [9]Additive Manufacturing Division,Singapore Institute of Manufacturing Technology(SIMTech),Agency for Science,Technology and Research(A∗STAR),5 Cleantech Loop 636732,Singapore [10]Department of Architectural Engineering,Hanyang University,Seoul,South Korea

出　　处：《Journal of Magnesium and Alloys》2024年第7期2569-2594,共26页镁合金学报（英文）

基　　金：supported by National Research Foundation of Korea(NRF)grants funded by the Korean Government(MSIT)[grant numbers RS-2023-00207763 and NRF-2022R1A2C2010350].

摘　　要：Magnesium(Mg)and its alloys have recently gained increasing attention in the biomedical field as promising biodegradable materials with harmless degradation products.Magnesium-based alloys have a wide range of biomedical applications because of their outstanding biocompatibility and unique mechanical properties.Widespread use of Mg-based biomedical devices eliminates the need for post-healing biomaterial removal surgery and minimizes the negative consequences of the implantation of permanent biomaterials,including stress shielding and undesired metal ion release in the body.This paper provides a literature review on the properties and manufacturing methods of Mgbased alloys for biomedical applications,including orthopedic implants,cardiovascular applications,surgical wires and staplers,and antitumor activities.Each application of Mg-based biomaterials is investigated from a biological perspective,including matching functional properties,biocompatibility,host tissue responses,and anti-microbial strategies,along with potential additive manufacturing technologies for these applications.Finally,an outlook is presented to provide recommendations for Mg-based biomaterials in the future.

关 键 词：Mg-based alloys BIOCOMPATIBILITY Anti-microbial strategies Additive manufacturing Mg implants 

分 类 号：R318[医药卫生—生物医学工程] TG146.22[医药卫生—基础医学]