Micro-alloying of Zn and Ca in vacuum induction casted bioresorbable Mg system:Perspectives on corrosion resistance,cytocompatibility,and inflammatory response  

作　　者：Manisha Behera Agnès Denys Rajashekhara Shabadi Fabrice Allain Cosmin Gruescu 

机构地区：[1]UnitéMatériaux et Transformations(UMET),Universitéde Lille,CNRS,INRA,ENSCL,UMR 8207,UMET,F-59000 Lille,France [2]Universitéde Lille,CNRS,UMR 8576-UGSF-Unitéde Glycobiologie Structurale et Fonctionnelle,F-59000 Lille,France

出　　处：《Journal of Magnesium and Alloys》2024年第7期2812-2825,共14页镁合金学报（英文）

基　　金：funded by European Union’s Horizon 2020 Research and Innovation program and‘Magnesium based Nano Composites for Orthopedic Applications’MAGNACOM,project under the aegis of Programme for Early-Stage Researchers(PEARL,I-Site ULNE under the Marie Sklodowska-Curie grant agreement);supported by University of Lille(France)and Hauts-de-France region.

摘　　要：There is an increasing interest in biodegradable materials,such as magnesium,for orthopaedic implants.This is driven by their potential to address challenges like stress shielding and the need for secondary removal surgery.In this study,biodegradable magnesium alloys were produced using the Vacuum Induction Casting technique.The impact of micro-alloying Zn and Ca in Mg-xZn-0.2Ca(x=0.1,0.2,0.3,and 0.4 wt%)alloys on corrosion resistance,cytocompatibility,and early-stage inflammatory response was investigated.XRD and SEM-EDS analysis confirmed the presence of Ca_(2)Mg_(6)Zn_(3)secondary phases in all alloys.The Mg-0.3Zn-0.2Ca alloy exhibited the lowest corrosion rate and an elastic modulus of 36.8 GPa,resembling that of natural bone.Electrochemical measurements indicated a correlation between grain size and secondary phase volume fraction in explaining corrosion behaviour.In vitro degradation in simulated body fluid(SBF)for 21 days showed hydroxyapatite formation on alloy surfaces,aligning with electrochemical studies.In vitro cytotoxicity tests demonstrated the cytocompatibility of all alloys,with Mg-0.3Zn-0.2Ca having the highest cell viability over a 6-day cell culture.Investigation into the inflammatory response with RAW-Blue macrophages revealed the anti-inflammatory properties of Mg-0.3Zn-0.2Ca alloys.Micro-alloying with 0.3 wt%Zn and 0.2 wt%Ca enhanced mechanical properties,corrosion resistance,cytocompatibility,and immunomodulatory properties.This positions the Mg-0.3Zn-0.2Ca alloy as a promising biodegradable implant for bone fixation applications.

关 键 词：Micro-alloying MgZnCa Corrosion resistance In vitro Anti-inflammatory response 

分 类 号：TG146.22[一般工业技术—材料科学与工程]