促胶原再生材料的临床应用进展  

Progress in clinical application of collagen-promoting materials

作　　者：张榕 孙怡馨 俞楠泽[1] 丁文蕴[1] 龙笑[1] ZHANG Rong;SUN Yixin;YU Nanze;DING Wenyun;LONG Xiao(Department of Plastic Surgery,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院整形外科,北京100730

出　　处：《中国美容整形外科杂志》2024年第10期639-640,I0003,I0004,共4页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：胶原再生是一个复杂的生物过程,涉及到多种细胞类型和多种生长因子。促胶原再生材料通常由生物材料或合成物质制成,可以刺激皮肤细胞的增殖和分化。目前市场上存在多种促胶原再生材料,但不同材料的效果和安全性存在差异。现就钙羟基磷灰石(calcium hydroxylapatite,Ca HA)、聚左旋乳酸(poly-L-lactic acid,PLLA)、聚己内酯(poly-caprolactone,PCL)3种促胶原再生材料的作用机制、应用及不良反应作一综述。Collagen regeneration is a complex biological process that involves a variety of cell types and growth factors.Pro-collagen regeneration materials are usually made of biological materials or synthetic substances,which can stimulate the proliferation and differentiation of skin cells.At present,there are many kinds of pro-collagen regeneration materials on the market,but the effects and safety of different materials are different.In this paper,the mechanism of action,application and adverse reactions of Calcium hydroxylapatite(CaHA),poly-L-lactic acid(PLLA)and poly-caprolactone(PCL),which promote collagen regeneration,are reviewed.

关 键 词：胶原再生 材料 注射技术 真皮填充剂 Ca HA PLLA PCL 

分 类 号：R318.08[医药卫生—生物医学工程]