核磁共振技术的定量方法综述  

A review of nuclear magnetic resonance quantitative technique

作　　者：周晓力[1] 李增鑫 刘万卉[2] 尹利辉[1] ZHOU Xiao-li;LI Zeng-xin;LIU Wan-hui;YIN Li-hui(National Institutes for Food and Drug Control,Beijing 102629,China;Yantai University,Yantai 264003,China)

机构地区：[1]中国食品药品检定研究院,北京102629 [2]烟台大学,烟台264003

出　　处：《药物分析杂志》2024年第10期1655-1664,共10页Chinese Journal of Pharmaceutical Analysis

基　　金：中国食品药品检定研究院关键技术研究基金项目(GJJS-2022-5-2);国家药品监督管理局化学药品质量研究与评价重点实验室项目(2023HYZX08)。

摘　　要：核磁共振技术不仅是优秀的定性技术,在定量方面,也有着其独特的优势。作为一种高选择性、快速、经济的定量分析方法,核磁定量技术已广泛应用于医药、化工、食品等领域。核磁共振定量技术的基本原理是检测的磁性核共振信号强度与相应核的数成正比,并可根据样品性质,灵活选择相应的技术手段和定量方法,具有广泛的应用价值。本文针对核磁定量技术的定量方法,结合相关文献报道应用研究成果进行了系统的总结,为其实际应用及研究提供借鉴。Nuclear magnetic resonance technology is not only an excellent qualitative technique,but also has its unique advantages in quantitative aspects.As a highly selective,fast,and economical quantitative analysis method,nuclear magnetic quantification technology has been widely applied in fields such as medicine,chemical industry,and food.The basic principle of nuclear magnetic resonance quantitative technology is that the strength of the detected magnetic resonance signal is proportional to the number of corresponding nuclear.Based on the properties of the sample,corresponding technical means and quantitative methods can be flexibly selected,which have wide application value.This article provides a systematic summary of the quantitative methods of nuclear magnetic quantification technology combined with relevant literature reports and research results,providing reference for its practical application and research.

关 键 词：核磁定量 基本原理 相对定量法 归一化法 内标法 外部标准法 电子参考获取体内浓度法 通过信号注入进行幅度矫正参考法 标准添加法 标准曲线法 基于脉冲长度的浓度测定法 人工信号量化法 

分 类 号：R917[医药卫生—药物分析学]