江苏射阳小型出生队列新生儿脐带血清中全氟和多氟烷基化合物水平及其影响因素  

Levels and influencing factors of perfluorinated and polyfluoroalkyl substances in umbilical cord serum from Sheyang Mini Birth Cohort Study,Jiangsu Province

作　　者：谭若男 王铮 张济明[1] 戴一鸣 郭剑秋 齐小娟[1,2] 卢大胜[3] 常秀丽[1] 邬春华[1] 周志俊[1] TAN Ruonan;WANG Zheng;ZHANG Jiming;DAI Yiming;GUO Jianqiu;QI Xiaojuan;LU Dasheng;CHANG Xiuli;WU Chunhua;ZHOU Zhijun(School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education,Fudan University,Shanghai 200032,China;Institute of Nutrition and Food Safety,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang 310051,China;Pesticide Reference and Dioxin Laboratory,Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China)

机构地区：[1]复旦大学公共卫生学院/公共卫生安全教育部重点实验室,上海200032 [2]浙江省疾病预防控制中心营养与食品安全所,浙江杭州310051 [3]上海市疾病预防控制中心农药参比与二噁英实验室,上海200336

出　　处：《环境与职业医学》2024年第8期841-848,共8页Journal of Environmental and Occupational Medicine

基　　金：上海市自然科学基金项目(18ZR1404200);上海市公共卫生三年行动计划重点学科建设项目(GWVI-11.1-41)。

摘　　要：[背景]全氟和多氟烷基化合物(PFAS)是一类生态环境中广泛存在的新污染物,对人体具有多器官毒性作用。评估脐带血清中PFAS的暴露水平及影响因素,可为研究PFAS暴露对母婴健康的影响和风险管控提供科学依据。[目的]评估新生儿脐带血清中PFAS暴露负荷水平及其影响因素。[方法]基于2009年建立的射阳小型出生队列中的母婴数据库和脐带血样本库,使用课题组自行设计的问卷收集孕妇的社会人口学信息、孕期居住环境和生活方式等信息,应用超高效液相色谱高分辨质谱仪检测1097份新生儿脐带血清中PFAS的质量浓度(后称浓度),采用多元线性回归模型分析脐带血清中PFAS暴露水平的影响因素。[结果]脐带血清中共检出38种PFAS,包括20种全氟羧酸类(PFCA)、14种全氟磺酸类(PFSA)和4种其他类型PFAS。有14种PFAS检出率在50%以上,其中全氟己烷磺酸(PFHxS)、全氟辛烷磺酸(PFOS)、全氟壬酸(PFNA)、全氟辛酸(PFOA)、全氟癸酸(PFDA)和全氟十一烷酸(PFUdA)的检出率为99.18%~100.00%,PFOA和6∶2氯代多氟烷基醚磺酸(6∶2 CI-PFESA)的中位浓度高于其他化合物,分别为3.76μg·L^(-1)和2.61μg·L^(-1)。脐带血清PFAS之间呈不同程度的相关(r=0.0911~0.8429,P<0.05),其中PFHxS与全氟庚烷磺酸(PFHpS)(r=0.8429,P<0.05)、PFOS与PFHpS(r=0.7012,P<0.05)、PFUdA与全氟十二烷酸(PFDoA)(r=0.7875,P<0.05)之间呈强相关。PFCA类和PFSA类化合物在脐带血清中的占比分别为60.1%和38.4%。PFOA和6∶2 Cl-PFESA是脐血清中最主要的2种化合物,占比分别为37.8%和19.3%。脐血清中不同类型的PFAS浓度与孕期母亲的年龄、产次、受教育水平、孕周、职业等人口学信息的关联不尽相同。多元线性回归分析结果发现:脐带血清中8种PFAS(PFHxS、PFHpS、PFNA、PFOS、PFDA、PFUdA、PFDoA和6∶2 CI-PFESA)的浓度在年龄≥25岁的孕妇中低于年龄<25岁的孕妇;与受教育水平在初中及以下的孕妇相比,[Background]Perfluorinated and polyfluoroalkyl substances(PFAS),a large group of emerging pollutants,are ubiquitous in the ecological environment.Their multiple organ toxic effects on human body are reported.Understanding the exposure level of PFAS in cord serum and associated influencing factors can provide scientific evidence for studying maternal and newborn health effects and risk regulation.[Objective]To explore the exposure levels of PFAS in cord serum and potential impact factors.[Methods]This study was based on the maternal and infant database and the cord serum sample bank of the Sheyang Mini Birth Cohort Study(SMBCS)established in 2009.A self-designed questionnaire was used to collect information on sociodemographic characteristics,living environment,and lifestyle of mothers during pregnancy.A total of 1097 cord serum samples were measured utilizing ultra-high performance liquid chromatography-Q-Exactive Orbitrap high-resolution mass spectrometry.Multiple linear regression models were used to identify influencing factors related to PFAS exposure level in cord serum.[Results]A total of 38 types of PFAS were detected in the cord serum samples,including 20 perfluorocarboxylic acids(PFCA),14 perfluorosulfonic acids(PFSA),and 4 other types of PFAS.The detection rates of 14 PFAS compounds were above 50%.The detection rates of perfluoro-1-hexanesulfonic acid(PFHxS),perfluoro-1-octanesulfonic acid(PFOS),perfluorononanoic acid(PFNA),perfluorooctanoic acid(PFOA),perfluorodecanoic acid(PFDA),and perfluoroundecanoic acid(PFUdA)were in the range of 99.18%-100.00%.The median concentrations of PFOA and 6∶2 chlorinated polyfluorinated ether sulfonic acid(6∶2CI-PFESA)were higher than those of the other compounds,which were 3.76µg·L^(-1)and 2.61µg·L^(-1),respectively.The correlation coefficients among cord serum PFAS were in the wide range of 0.0911-0.8429(P<0.05).The associations between PFHxS and perfluoro-1-heptanesulfonic acid(PFHpS)(r=0.8429,P<0.05),PFOS and PFHpS(r=0.7012,P<0.05),and PFUdA and perfluorodode

关 键 词：全氟和多氟烷基物质 暴露负荷 脐带血清 新污染物 

分 类 号：R12[医药卫生—环境卫生学]