老年高血压合并糖尿病患者餐后低血压与血糖波动的关系  

Relationship between postprandial hypotension and blood glucose fluctuation in elderly hypertensive patients with diabetes

作　　者：陈泓颖 鲁常红 张宇航 于浩 董笑然 刘英娣 CHEN Hongying;LU Changhong;ZHANG Yuhang;YU Hao;DONG Xiaoran;LIU Yingdi(Dept.of Geriatrics,Electric Power Teaching Hospital,Capital Medical University,Beijing 100073,China)

机构地区：[1]首都医科大学电力教学医院老年病科,北京100073

出　　处：《武汉大学学报（医学版）》2024年第10期1202-1206,共5页Medical Journal of Wuhan University

基　　金：国家重点研发计划资助项目(编号:2018YFC2002104)。

摘　　要：目的:分析老年高血压合并糖尿病患者餐后低血压发生情况及其与血糖波动间的关系。方法:纳入2019年1月—2022年7月期间首都医科大学电力教学医院接收的489例老年高血压合并糖尿病患者,统计所有患者餐后低血压发生情况并分为发生组与未发生组,测定血糖波动指标,分析老年高血压合并糖尿病患者餐后低血压对血糖波动的影响。结果:研究共纳入489例老年高血压合并糖尿病患者,其中发生餐后低血压的共281例(57.46%),未发生的有208例(42.54%);发生组三餐前平均收缩压及舒张压、糖化血红蛋白(HbA1c)、空腹血糖(FBG)水平高于未发生组,差异有统计学意义(P<0.05);发生组血糖水平标准差(SDBG)、最大血糖波动幅度(LAGE)、餐后血糖波动幅度(PPGE)、平均血糖波动幅度(MAGE)、血糖平均水平(MBG)、餐后收缩压下降幅度值均高于未发生组,差异有统计学意义(P<0.05);经一般双变量Pearson相关性证实,餐后收缩压下降幅度与老年高血压合并糖尿病患者血糖波动呈正相关(r>0,P<0.05)。结论:老年高血压合并糖尿病患者发生餐后低血压风险较高,发生餐后低血压的患者血糖波动幅度更大。Objective:To analyze the incidence of postprandial hypotension in elderly hypertensive patients with diabetes and its relationship with blood glucose fluctuation.Methods:A total of 489 elderly patients with hypertension and diabetes received by Electric Power Teaching Hospital of Capital Medical University from January 2019 to July 2022 were included.The occurrence of postprandial hypotension in all patients was counted and divided into an occurrence group and a non-occurrence group.The blood glucose fluctuation index was measured to analyze the influence of postprandial hypotension on blood glucose fluctuation in elderly hypertensive patients with diabetes.Results:A total of 489 elderly patients with hypertension and diabetes were included in the study,with 281(57.46%)cases in occurrence group,and 208(42.54%)in non-occurrence group according to the occurrence of postprandial hypotension.The mean pre-prandial systolic and diastolic blood pressure,HbA1c,and fasting bloodglucose(FBG)levels in the occurrence group were higher than those in the non-occurrence group(P<0.05).The decrease of blood glucose indices such as SDBG,LAGE,PPGE,MAGE,MBG,and postprandial systolic blood pressure in the occurrence group was higher than those in the non-occurrence group(P<0.05).Pearson correlation confirmed that the decrease in postprandial systolic blood pressure was positively correlated with the fluctuation of blood glucose in elderly hypertensive patients with diabetes(r>0,P<0.05).Conclusion:Elderly patients with hypertension and diabetes have a higher risk of postprandial hypotension,and patients with postprandial hypotension have greater blood glucose fluctuation.

关 键 词：高血压 糖尿病 餐后低血压 血糖波动 

分 类 号：R587.1[医药卫生—内分泌]